Myocardial regeneration by targeting to microRNA

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We investigated whether controlled release of antagomir designed to inhibit microRNA-92a leads to enhanced blood vessel growth and functional recovery after myocardial infarction (MI) in rats. There was no difference in LV wall motion between rats with the antagomir-92a patch and the patch alone 1 hour after MI. However, myocardial thinning was inhibited, and LV wall motion was improved 3 days after MI in rats with the antagomir-92a patch. Myocardial fibrosis was reduced by the antagomir-92a patch 14 days after MI. Angiogenesis within the infarct area was increased by the antagomir-92a patch associated with enhanced cardiomyogenesis. The patch alone or the patch impregnated with antagomir-Co had no effect on LV wall motion, myocardial fibrosis, angiogenesis and cardiomyogenesis after MI. These results suggest that controlled release of antagomir-92a using gelatin hydrogel microspheres-incorporated patch is an effective tool for cardiac regeneration therapy after MI.