Analysis of angiogenetic factor in interstitial pneumonia

间质性肺炎血管生成因子分析

• 批准号: 23591164
• 负责人: KUNUGI Shinobu
• 金额: $ 3.24万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591164/
• 关键词: 間質性肺炎; 肺胞上皮; miRNA; microRNA; exosome; multivesicular body; 血管新生; 血管新生抑制薬

We have been investigated pathogenesis of early intra-alveolar fibrotic process in interstitial pneumonia. We showed fibroblast differentiation into myofibroblast and decreased neovasculization in intra-alveolar fibrotic lesion of idiopathic pulmonary fibrosis. However, there is only limited information concerning the role of miroRNA in lung fibrotic process. Forthermore, microRNA and exosomal microRNA in bronchoalveolar lavage in lung fibrotic process are not investigated. We investigate exosomal microRNA in brochoalveolar lavage flood in mouse model of bleomycin induced lug fibrosis.

我们已经研究了间质性肺炎早期肺泡内纤维化过程的发病机制。我们发现，在特发性肺纤维化的肺泡内纤维化病变中，成纤维细胞分化为肌成纤维细胞，新生血管形成减少。 然而，关于miRNA在肺纤维化过程中的作用的信息有限。支气管肺泡灌洗液中的microRNA和外泌体microRNA在肺纤维化过程中未被研究。我们研究了博莱霉素诱导的肺纤维化小鼠模型中支气管肺泡灌洗液中的外泌体microRNA。

项目成果

Familial interstitial pneumonia in an adolescent boy with surfactant protein C gene (Y104H)

一名携带表面活性蛋白 C 基因（Y104H）的青春期男孩的家族性间质性肺炎

• 发表时间: 2013
• 期刊: Sarcoidosis Vasc Diffuse Lung Dis.
• 作者: Kuse N;Abe S;Hayashi H;Kamio K;Saito Y;Azuma A;Kudoh S;Kunugi S;Fukuda Y;Setoguchi Y;Gemma A.
• 通讯作者: Gemma A.

間質性肺炎の基本と考え方:病理.,臨床画像

间质性肺炎的基础知识和概念：病理学、临​​床图像

• 发表时间: 2014
• 作者: 功刀しのぶ;福田悠
• 通讯作者: 福田悠

Immunoglobulin G4-related lung disease: Clinicoradiological and pathological features

• DOI: 10.1111/resp.12016
• 发表时间: 2013-04-01
• 期刊: RESPIROLOGY
• 影响因子: 6.9
• 作者: Matsui, Shoko;Hebisawa, Akira;Ogura, Takashi
• 通讯作者: Ogura, Takashi

Role of survivin in acute lung injury: epithelial cells of mice and humans

• DOI: 10.1038/labinvest.2013.103
• 发表时间: 2013-10-01
• 期刊: LABORATORY INVESTIGATION
• 影响因子: 5
• 作者: Terasaki, Yasuhiro;Terasaki, Mika;Fukuda, Yuh
• 通讯作者: Fukuda, Yuh

The localization of chains of Type IV collagen in

本地化

• 发表时间: 2011
• 作者: .Urushiyama H;Terasaki Y;Amenomori S;Tersaki M;Kunugi S(6/9),
• 通讯作者: Kunugi S(6/9),