Identification and characterization of susceptibility genes for type 1 diabetes in the major histocompatibility complex

主要组织相容性复合体中 1 型糖尿病易感基因的鉴定和表征

• 批准号: 23591328
• 负责人: KAWABATA Yumiko
• 金额: $ 3.41万
• 依托单位: Kinki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591328/
• 关键词: 1型糖尿病; 遺伝子; HLA; １型糖尿病

To clarify genetic susceptibility to type 1 diabetes in the major histocompatibility complex , we robustly investigated the association of HLA-DRB1, DQB1, A, B, C loci with type 1 diabetes. This study showed that the frequency of the combination of DRB1*04:05-DQB1*04:01 and DRB1*08:02-DQB1*03:02 was low in Japanese population, but this was very high risk combination to type 1 diabetes. Several alleles of B, C loci were associated with type 1 diabetes, but most of them appeared to be secondary to linkage disequilibrium between these alleles and disease-related class II alleles. Taken the result with autoimmune thyroid disease in consideration, these data suggest that HLA Class II and Class I might contribute to the genetic susceptibility in the different manner, for each specific target organ.

为了阐明主要组织相容性复合体中1型糖尿病的遗传易感性，我们稳健地调查了HLA-DRB 1、DQB 1、A、B、C位点与1型糖尿病的关联。本研究表明，DRB 1 *04：05-DQB 1 *04：01和DRB 1 *08：02-DQB 1 *03：02组合在日本人群中的频率较低，但这是1型糖尿病的非常高风险组合。B、C基因座的一些等位基因与1型糖尿病相关，但大多数等位基因与疾病相关的II类等位基因之间的连锁不平衡是次要的。考虑到自身免疫性甲状腺疾病的结果，这些数据表明HLA II类和I类可能以不同的方式对每个特定靶器官的遗传易感性做出贡献。

项目成果

Type 1 diabetes and interferon therapy: a nationwide survey in Japan.

• DOI: 10.2337/dc10-2274
• 发表时间: 2011-09
• 期刊: Diabetes care
• 影响因子: 16.2
• 作者: Nakamura K;Kawasaki E;Imagawa A;Awata T;Ikegami H;Uchigata Y;Kobayashi T;Shimada A;Nakanishi K;Makino H;Maruyama T;Hanafusa T;Research Committee on Type 1 Diabetes of the Japan Diabetes Society
• 通讯作者: Research Committee on Type 1 Diabetes of the Japan Diabetes Society

Prolonged hyperinsulinemia after subcutaneous injection of 2400 U regular insulin in a suicide attempt: Time course of serum insulin with frequent measurements.

• DOI: 10.1111/j.2040-1124.2012.00211.x
• 发表时间: 2012-10-18
• 期刊: Journal of diabetes investigation
• 影响因子: 3.2
• 作者: Hiromine Y;Kawabata Y;Yamauchi T;Noso S;Babaya N;Harada T;Ito H;Ikegami H
• 通讯作者: Ikegami H

家系内に自己免疫性甲状腺疾患が多発し、多腺性自己免疫症候群III-A型に骨髄異形成症候群を合併した1例

因家族中多发自身免疫性甲状腺疾病而导致III-A型多腺体自身免疫综合征合并骨髓增生异常综合征1例。

• 发表时间: 2013
• 期刊: 糖尿病
• 作者: 日高周次;川畑由美子;中山俊之;加島尋;光冨公彦;石田健朗;藤富豊;野口仁志;福永淳治;池上博司;吉松博信
• 通讯作者: 吉松博信

Meta-analysis of genome-wide association studies identifies 8 new loci for type 2 diabetes in East Asians

全基因组关联研究的荟萃分析确定了东亚人 2 型糖尿病的 8 个新位点

• 发表时间: 2012
• 期刊: Nature Genet
• 作者: Fujimoto S;Mukai E;Inagaki N;Ikegami H(他67名)
• 通讯作者: Ikegami H(他67名)

Mafa knockout NOD mice are protected from type 1 diabetes despite accelerated infiltration of lymphocytes into islets

Mafa 基因敲除 NOD 小鼠尽管淋巴细胞加速渗入胰岛，但仍能免受 1 型糖尿病影响

• 发表时间: 2013
• 作者: Moran I;Akerman I;van de Bunt M;Xie R;Benazra M;Nammo T;et al.;Kawabata Y(他4名)
• 通讯作者: Kawabata Y(他4名)