Elucidation of the subgroup existence of HLA class II polymorphism (DP, DQ, DR) in Kawasaki disease patients

本研究旨在检测川崎病(KD)患者的人类白细胞抗原II类亚型和粪便中检出的超抗原(SAG)基因，以证实存在对每种SAG敏感的亚群，并证实人类白细胞抗原II亚型是KD发病的宿主因素之一。具体地说，我们检测了KD患儿和对照儿童粪便DNA中的SAG基因，并检测了其血液中的人类白细胞抗原II亚型。并探讨了SAG与人类白细胞抗原II亚型的关系。但我们落后于开始一项实验，因为选择合适的分析系统需要时间。此外，样本收集不足，因为这三年的KD病例数量略少。因此，我们目前正在研究这一主题。我们想多收集一点样本，继续这项研究。

In this study, we aimed to examine HLA class II subtype of Kawasaki disease (KD) patient and superantigen (SAg) gene detected from his stool, and to prove that there were subgroups of HLA class II subtype which were sensitive to each SAg and that HLA class II subtype was one of the host factors related to KD onset. Concretely, we detected SAg genes in all DNA extracted from KD patients' and control children's stools, and detected HLA class II subtypes in DNA extracted from their blood samples. And we studied the relation between SAg and HLA class II subtypes. But we were behind with starting an experiment because choice of appropriate analyzing system for HLA took time. Furthermore, samples did not gather enough because there was slightly little number of cases of KD for these three years. Therefore we are studying this theme at present. We want to collect samples a little more and continue this study.