The new approach method for the vascularization mechanism elucidation of the non-small-cell lung cancer and the clinical application
The new approach method for the vascularization mechanism elucidation of the non-small-cell lung cancer and the clinical application
批准号:
23592069
负责人:
SUZUKI Makoto
金额:
$3.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
中文摘要
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英文摘要
We examined a role of five genes ( LINE-1, SLIT2, MAL, IGFBP7, IRF8 ) including the gene which relates to angigogenesis, in terms of the carcinogenesis and invasion of non-small cell lung cancer (NSCLC). As a result, in NSCLC, LINE-1 was hypomethylated and expressions of other SLIT2, MAL, IGFBP7, and IRF8 were lowered by hypermethylation of their genes. Because the changes were tumor-specific when compared with non-malignant lung tissues, further study will clarify the mechanism of carcinogenesis of NSCLC and will contribute to the new treatment of NSCLC.
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