Function and regulatory mechanism of the microtubule cytoskeleton required for epithelial morphogenesis in vivo
Function and regulatory mechanism of the microtubule cytoskeleton required for epithelial morphogenesis in vivo
批准号:
21870043
负责人:
SUZUKI Makoto
金额:
$1.76万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Research Activity Start-up
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
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英文摘要
To understand the function and regulatory mechanisms of microtubule cytoskeleton in epithelial morphogenesis in vivo, we performed cell biological analyses of neural tube formation in Xenopus and zebrafish embryos. Results presented here showed that correct microtubule organization positively regulates cell elongation, one of the important cellular behaviors in the neuroepithelial cells. We also found that xMID and Mig12 proteins were involved in microtubule-mediated cell elongation. These findings would help us to understand pathological mechanisms of various disorders in human, resulted from the abnormalities in epithelial tissues.
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Regulation of microtubule organization by xMID is essential for maintaining tissue integrity in Xenopus neural tube closure (WS6-04).
xMID 对微管组织的调节对于维持爪蟾神经管闭合 (WS6-04) 中的组织完整性至关重要。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[堀越直樹、立和名博昭、齋藤健吾, et al., 鈴木誠,原祐介,山本隆正,高木知世,上野直人]
通讯作者:
鈴木誠,原祐介,山本隆正,高木知世,上野直人
DOI:
10.1016/j.ydbio.2009.11.026
发表时间:
2010-02
期刊:
Developmental biology
影响因子:
2.7
作者:
[Shiro Ohgo;A. Itoh;Makoto Suzuki;A. Satoh;H. Yokoyama;K. Tamura]
通讯作者:
Shiro Ohgo;A. Itoh;Makoto Suzuki;A. Satoh;H. Yokoyama;K. Tamura
DOI:
10.1242/dev.048769
发表时间:
2010-07-15
期刊:
DEVELOPMENT
影响因子:
4.6
作者:
[Suzuki, Makoto, Hara, Yusuke, Ueno, Naoto]
通讯作者:
Ueno, Naoto
神経管の形成における細胞の伸長と細胞骨格によるその制御機構(ナイトレクチャー)
神经管形成中的细胞伸长及其细胞骨架的控制机制(夜间讲座)
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[森脇義仁, 佐藤昌彦, 長土居有隆, 立和名博昭, 胡桃坂仁志, 西村善文, 鈴木誠]
通讯作者:
鈴木誠
Regulation of microtubule organization by xMID is essential for maintaining tissue integrity in Xenopus neural tube closure
xMID 对微管组织的调节对于维持非洲爪蟾神经管闭合中的组织完整性至关重要
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Suzuki, M.]
通讯作者:
M.
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