Second messenger systems required for epithelial morphogenesis in vivo
Second messenger systems required for epithelial morphogenesis in vivo
批准号:
23770261
负责人:
SUZUKI Makoto
金额:
$2.91万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
中文摘要
为了了解第二信使系统在上皮细胞形态发生中的功能和调控机制,我们对非洲爪蟾和斑马鱼胚胎神经管形成进行了细胞生物学分析。这里提供的结果表明,细胞内钙离子信号传导正调节神经上皮细胞重要的细胞行为之一--顶端收缩。我们还发现,细胞外ATP参与钙介导的根尖收缩。这些发现将有助于我们了解人类上皮组织异常导致的各种疾病的病理机制。
英文摘要
To understand function and regulatory mechanism of second messenger systems in epithelial morphogenesis in vivo, we performed cell biological analyses of neural tube formation in Xenopus and zebrafish embryos. Results presented here showed that intracellular calcium ion signaling positively regulates apical constriction, one of the important cellular behaviors in the neuroepithelial cells. We also found that extracellular ATP was involved in calcium-mediated apical constriction. These findings would help us to understand pathological mechanisms of various disorders in human, resulted from the abnormalities in epithelial tissues.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
Spatio-temporal pattern of non-muscle myosin II activity in zebrafish neurulation
斑马鱼神经中非肌肉肌球蛋白 II 活性的时空模式
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[GG Leblond, H Sarazin, R Li, M Suzuki, N Ueno, XJ Liu, Makoto Suzuki, 鈴木誠, 鈴木誠, 鈴木誠, 鈴木誠, 鈴木誠, 鈴木誠, 鈴木誠, 鈴木誠, 鈴木誠, 鈴木誠, Makoto Suzuki, 鈴木誠]
通讯作者:
鈴木誠
脊椎動物の神経管にみる細胞の挙動とその制御機構
脊椎动物神经管细胞的行为及其控制机制
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[GG Leblond, H Sarazin, R Li, M Suzuki, N Ueno, XJ Liu, Makoto Suzuki, 鈴木誠, 鈴木誠, 鈴木誠, 鈴木誠, 鈴木誠, 鈴木誠, 鈴木誠, 鈴木誠, 鈴木誠, 鈴木誠]
通讯作者:
鈴木誠
上皮性器官の形態形成を支える細胞と細胞骨格の動態の制御
支持上皮器官形态发生的细胞和细胞骨架动力学调节
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[GG Leblond, H Sarazin, R Li, M Suzuki, N Ueno, XJ Liu, Makoto Suzuki, 鈴木誠, 鈴木誠, 鈴木誠, 鈴木誠]
通讯作者:
鈴木誠
Control of apical constriction by dynamic calcium signaling during Xenopus neural tube closure
非洲爪蟾神经管闭合过程中动态钙信号控制顶端收缩
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[GG Leblond, H Sarazin, R Li, M Suzuki, N Ueno, XJ Liu, Makoto Suzuki, 鈴木誠, 鈴木誠, 鈴木誠, 鈴木誠, 鈴木誠, 鈴木誠]
通讯作者:
鈴木誠
ゼブラフィッシュ神経管における周期的な収斂運動
斑马鱼神经管的周期性收敛运动
DOI:
--
发表时间:
2014
期刊:
影响因子:
--
作者:
[GG Leblond, H Sarazin, R Li, M Suzuki, N Ueno, XJ Liu, Makoto Suzuki, 鈴木誠]
通讯作者:
鈴木誠
共 11 条
証明指導の改善に関する研究ー方針を立てることや読むことを通してー
-
批准号:20H00793
-
项目类别:Grant-in-Aid for Encouragement of Scientists
-
资助金额:$0.22万
-
财政年份:2020
-
负责人:SUZUKI Makoto
-
依托单位:
Novel intervention strategy for acquiring smooth behaviors: neural synchronization and behavioral learning
-
批准号:18H03133
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.23万
-
财政年份:2018
-
负责人:SUZUKI Makoto
-
依托单位:
A novel intervention to modulate reciprocal inhibition function: effects of electromagnetic stimulation and afferent feedback
-
批准号:18K19750
-
项目类别:Grant-in-Aid for Challenging Research (Exploratory)
-
资助金额:$3.99万
-
财政年份:2018
-
负责人:SUZUKI Makoto
-
依托单位:
A deplopmental study on cultural instituions
-
批准号:15K01149
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.0万
-
财政年份:2015
-
负责人:SUZUKI Makoto
-
依托单位:
Research of Universal Management in Public Japanese Gardens in the Modern World
-
批准号:26292187
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.9万
-
财政年份:2014
-
负责人:SUZUKI Makoto
-
依托单位:
Research in the Reforms of the Eight Banners during the Reign of Emperor Yongzheng of the Qing Dynasty and the Appointment of Bannermen Bureaucrats
-
批准号:25370846
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.58万
-
财政年份:2013
-
负责人:SUZUKI Makoto
-
依托单位:
Paired associative stimulation for smooth movement: change in reciprocal inhibition
-
批准号:23700633
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.83万
-
财政年份:2011
-
负责人:SUZUKI Makoto
-
依托单位:
The new approach method for the vascularization mechanism elucidation of the non-small-cell lung cancer and the clinical application
-
批准号:23592069
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.33万
-
财政年份:2011
-
负责人:SUZUKI Makoto
-
依托单位:
The response of a bony single cell to the quantitive mechanical stress by an atomic force microscope
-
批准号:22890022
-
项目类别:Grant-in-Aid for Research Activity Start-up
-
资助金额:$1.91万
-
财政年份:2010
-
负责人:SUZUKI Makoto
-
依托单位:
Qing Dynasty imperial succession during the Kangxi Era from the perspective of movements among banner princes
-
批准号:22720274
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.25万
-
财政年份:2010
-
负责人:SUZUKI Makoto
-
依托单位:
Text Mining for Languages of All Ages and Countries
-
批准号:22500140
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.66万
-
财政年份:2010
-
负责人:SUZUKI Makoto
-
依托单位:
Function and regulatory mechanism of the microtubule cytoskeleton required for epithelial morphogenesis in vivo
-
批准号:21870043
-
项目类别:Grant-in-Aid for Research Activity Start-up
-
资助金额:$1.76万
-
财政年份:2009
-
负责人:SUZUKI Makoto
-
依托单位:
Body dysfunction in patients with Alzheimer's disease
-
批准号:21800066
-
项目类别:Grant-in-Aid for Research Activity Start-up
-
资助金额:$1.64万
-
财政年份:2009
-
负责人:SUZUKI Makoto
-
依托单位:
A RESEARCH ON DEVEROPMENTAL PROCESS OF SOCIAL EDUCATION : FOCUSING ON THE ORIGINALITY AND THE SYSTEMATIZATION
-
批准号:21530849
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.83万
-
财政年份:2009
-
负责人:SUZUKI Makoto
-
依托单位:
The Role and Significance of Japanese Gardens outsideJapan in International Communities
-
批准号:20380023
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.81万
-
财政年份:2008
-
负责人:SUZUKI Makoto
-
依托单位:
Tai-or-madetreat ment for lung cancer using EBUS-TBNA
-
批准号:19591611
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.91万
-
财政年份:2007
-
负责人:SUZUKI Makoto
-
依托单位:
The Eight Banners of the Qing Dynasty and salt administration
-
批准号:19720180
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.47万
-
财政年份:2007
-
负责人:SUZUKI Makoto
-
依托单位:
Osmosensing mechanism of co-operation of Nax and TRPV4 channel
-
批准号:18590899
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.49万
-
财政年份:2006
-
负责人:SUZUKI Makoto
-
依托单位:
Prediction of lung cancer prognosis, and anticancer drug sensitivity by diversified clinical-gene set screening through microarray analysis, mutation, and aberrant methylation
-
批准号:18591540
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.49万
-
财政年份:2006
-
负责人:SUZUKI Makoto
-
依托单位:
Designing a new evaluation standard and its teaching method for the next generation's science education
-
批准号:18300260
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.82万
-
财政年份:2006
-
负责人:SUZUKI Makoto
-
依托单位: