To explore miR-195 mechanisms of acquired resistance against TMZ in glioblastoma.
To explore miR-195 mechanisms of acquired resistance against TMZ in glioblastoma.
探讨胶质母细胞瘤中 miR-195 对 TMZ 获得性耐药的机制。
批准号：
23592095
负责人：
UJIFUKU Kenta
金额：
$3.33万
依托单位：
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2011
资助国家：
日本
项目状态：
已结题
起止时间：
2011 至 2013
中文摘要
翻译
本研究的初步目的是探讨胶质母细胞瘤(GBM)对TMZ获得性耐药的miR-195机制。已经获得了意想不到的结果，但尚未发表。另一种研究方法已经进行，并获得了耐人寻味的结果。本研究旨在探讨GBM入侵前部生态位的机制。采用新的体外血脑屏障(BBB)模型，探讨血脑屏障与GBM之间的相互作用。在相互作用的急性期，GBM可增强血脑屏障，可能与成纤维细胞生长因子-2有关。这些成果已经发表。
英文摘要
The initial purpose of this study was to explore miR-195 mechanisms of acquired resistance against TMZ in glioblastoma (GBM). Unexpected results have been obtained and they have not been published yet.Alternative study approach has been performed and intriguing results have been obtained. This study was examined to explore the mechanism of invasion front niche of GBM. Using new in vitro blood brain barrier (BBB) models, interaction between BBB and GBM was explored. In acute phase of the interaction, GBM could strengthen BBB, and FGF-2 might be implicated in the process. These results have been published.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
DOI：
10.1186/1479-5876-9-30
发表时间：
2011-03-22
期刊：
Journal of translational medicine
影响因子：
7.4
作者：
[Matsushima K, Isomoto H, Yamaguchi N, Inoue N, Machida H, Nakayama T, Hayashi T, Kunizaki M, Hidaka S, Nagayasu T, Nakashima M, Ujifuku K, Mitsutake N, Ohtsuru A, Yamashita S, Korpal M, Kang Y, Gregory PA, Goodall GJ, Kohno S, Nakao K]
通讯作者：
Nakao K
Exploration of pericyte-derived factors implicated in lung cancer brain metastasis protection; a pilot messenger RNA sequencing using the blood-brain barrier in vitro model.
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批准号：17K10839
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项目类别：Grant-in-Aid for Scientific Research (C)
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资助金额：$2.91万
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财政年份：2017
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负责人：UJIFUKU Kenta
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依托单位：
海外基金
