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To explore miR-195 mechanisms of acquired resistance against TMZ in glioblastoma.

To explore miR-195 mechanisms of acquired resistance against TMZ in glioblastoma.
探讨胶质母细胞瘤中 miR-195 对 TMZ 获得性耐药的机制。
批准号：
23592095
负责人：
UJIFUKU Kenta
金额：
$3.33万
依托单位：
Nagasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2011
资助国家：
日本
项目状态：
已结题
起止时间：
2011 至 2013
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592095/
关键词：
脳腫瘍神経膠芽腫脳血管関門FGF-2Niche脳血管関門モデル悪性腫瘍核酸組織細胞脳神経疾患マイクロRNAマイクロＲＮＡ

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中文摘要
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英文摘要
The initial purpose of this study was to explore miR-195 mechanisms of acquired resistance against TMZ in glioblastoma (GBM). Unexpected results have been obtained and they have not been published yet.Alternative study approach has been performed and intriguing results have been obtained. This study was examined to explore the mechanism of invasion front niche of GBM. Using new in vitro blood brain barrier (BBB) models, interaction between BBB and GBM was explored. In acute phase of the interaction, GBM could strengthen BBB, and FGF-2 might be implicated in the process. These results have been published.
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会议论文
MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells.
DOI： 10.1186/1479-5876-9-30
发表时间： 2011-03-22
期刊： Journal of translational medicine
影响因子： 7.4
作者： [Matsushima K, Isomoto H, Yamaguchi N, Inoue N, Machida H, Nakayama T, Hayashi T, Kunizaki M, Hidaka S, Nagayasu T, Nakashima M, Ujifuku K, Mitsutake N, Ohtsuru A, Yamashita S, Korpal M, Kang Y, Gregory PA, Goodall GJ, Kohno S, Nakao K]
通讯作者： Nakao K
Exploration of pericyte-derived factors implicated in lung cancer brain metastasis protection; a pilot messenger RNA sequencing using the blood-brain barrier in vitro model.
  • 批准号：
    17K10839
  • 项目类别：
    Grant-in-Aid for Scientific Research (C)
  • 资助金额：
    $2.91万
  • 财政年份：
    2017
  • 负责人：
    UJIFUKU Kenta
  • 依托单位：
    Nagasaki University
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