Identification of novel genes for retinoic acid receptors and its function in endometrial cancer.

视黄酸受体新基因的鉴定及其在子宫内膜癌中的功能。

• 批准号: 23592432
• 负责人: UTSUNOMIYA Hiroki
• 金额: $ 3.24万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592432/
• 关键词: 子宮内膜癌; レチノイン酸; エストロゲン受容体; レチノイン酸受容体; SMAD3; クロマチン免疫沈降クローニング; 培養細胞

We focused on the novel target areas of mutual transcription factor for RARa and ERa. And then, we tried to detect the genes and its novel molecular mechanism.At first, we revealed the opposite functions between RARa and ERa. And then, we studied the target binding area of RARa and ERa using ChIP cloning technique, and found the promoter lesions of SMAD3. In addition, SMAD3 was significantly decreased after knock-down for RARa and addition of AM580 treatment compared with the control data.Our findings suggested that SMAD3 genes, which were deeply correlated with AM580 treatment, might play important biological roles in endometrial cancer.

我们重点关注RAR α和ER α相互转录因子的新靶区。本研究首先揭示了RARa和ER α的功能相反，并对RARa和ER α之间的相互作用机制进行了初步的研究。利用ChIP克隆技术对RARa和ERa的靶结合区进行了研究，发现SMAD3的启动子损伤。此外，SMAD3基因在RARa基因敲除和AM580治疗后均显著降低，提示与AM580治疗密切相关的SMAD3基因可能在子宫内膜癌中发挥重要的生物学作用。

项目成果

Individualized radical hysterectomy procedure using intraoperative electricalstimulation for patientswith cervical cancer

宫颈癌患者术中电刺激个体化根治性子宫切除术

• DOI: 10.1097/igc.0b013e31826fd684
• 发表时间: 2012
• 期刊: Int J Gynecol Cancer
• 影响因子: 4.8
• 作者: Nagai T;Niikura H;Kurosawa H;Tanaka S;Otsuki T;Utunomiya H;Nagase S;Takano T;Ito K;Kaiho Y;Nakagawa H;Arai Y;Yaegashi N
• 通讯作者: Yaegashi N

Laparoscopic Strassman Metroplasty in a Postmenarcheal Adolescent Girl With Herlyn-Werner-Wunderlich Mullerian Anomaly Variant, Obstructed Noncommunicating Didelphic Uterus Without Gartner Duct Pseudocyst

• DOI: 10.1016/j.jmig.2012.10.016
• 发表时间: 2013-03-01
• 期刊: JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
• 影响因子: 4.1
• 作者: Nabeshima, Hiroshi;Nishimoto, Mitsuo;Yaegashi, Nobuo
• 通讯作者: Yaegashi, Nobuo

Small Cell Carcinoma of the Uterine Cervix: Clinical Outcome of Concurrent Chemoradiotherapy with a Multidrug Regimen

• DOI: 10.1620/tjem.229.75
• 发表时间: 2013-01-01
• 期刊: TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
• 影响因子: 2.2
• 作者: Tokunaga, Hideki;Nagase, Satoru;Yaegashi, Nobuo
• 通讯作者: Yaegashi, Nobuo

Identification of novel estrogen receptorαtarget gene and its function in endometrial cancer

新型雌激素受体α靶基因的鉴定及其在子宫内膜癌中的作用

• 发表时间: 2012
• 作者: Shogo Shigeta;Hiroki Utsunomiya;et al
• 通讯作者: et al

Food Intake and the Risk of Endometrial Endometrioid Adenocarcinoma in Japanese Women

• DOI: 10.1080/01635581.2013.818158
• 发表时间: 2013-10-01
• 期刊: NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
• 影响因子: 2.9
• 作者: Takayama, Shin;Monma, Yasutake;Yaegashi, Nobuo
• 通讯作者: Yaegashi, Nobuo