Neuroprotection of experimental autoimmune optic neuritis by retinoid

在本研究中，我们研究了全反式维甲酸（ATRA）是否可以减轻小鼠实验性自身免疫性视神经炎（EAON）的程度。通过用髓鞘少突胶质细胞糖蛋白35 -55免疫C57 BL/6小鼠来诱导视神经炎。 从第0天至第20天，每隔一天给予ATRA（350 μ g/小鼠/时间点）。 组织病理学分析表明，ATRA治疗显著降低了EAE的临床评分和视神经炎的严重程度。 在ATRA处理的小鼠中，引流淋巴结细胞产生的IFN-g和IL-17显著减少。ATRA治疗后EAE小鼠视神经脱髓鞘程度明显减轻。 这些发现表明，ATRA治疗能够降低EAE小鼠视神经炎的严重程度。

In the present study, we investigated whether all trans-retinoic acid (ATRA) can reduce the degree of experimental autoimmune optic neuritis (EAON) in mice. Optic neuritis was induced in C57BL/6 mice by immunizing them with myelin oligodendrocyte glycoprotein35-55. ATRA (350 ug/mouse/time point) was administered every other day from day 0 to day 20. ATRA treatment significantly reduced the clinical score of EAE and the severity of the optic neuritis by histopathological analysis. The production of IFN-g and IL-17 by draining lymph node cells was significantly reduced in ATRA-treated mice. The degree of demyelination in the optic nerve of mice with EAE was significantly reduced after ATRA treatment. These findings demonstrate that ATRA treatment was able to reduce the severity of optic neuritis in mice with EAE.