Study of cerebral cortical mechanisms possibly responsible for jaw-movement disorders

可能导致下颌运动障碍的大脑皮层机制的研究

• 批准号: 23592699
• 负责人: YOSHIDA Atsushi
• 金额: $ 3.33万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592699/
• 关键词: 顎運動; 三叉神経運動核; 運動ニューロン; 大脳皮質; 脳; 神経; 解剖; 歯学; 咀嚼; 顎; 抑制性ニューロン; 頤

Electrical stimulation of the primary somatosensory cortex and the lateral part of the prefrontal cortex (insular cortex) as well as the lateral part of the agranular cortex induced jaw-movements which are specific for the cortical location stimulated. However, stimulation of the medial part of the agranular cortex did not induce any jaw-movements. These cortical areas sent direct projections to the trigeminal sensory nuclear complex and the reticular formation around the trigeminal motor nucleus both of which include excitatory and/or inhibitory premotoneurons. Note that such premotoneurons were also found in the solitary tract nucleus.These results may indicate that several indirect projections from the cerebral cortical areas to the trigeminal motor nucleus via its premotoneurons are involved in the induction of the characteristic jaw-movements, and the jaw-movement disorders are attributed to the disorders of the indirect projection systems from the cerebral cortical areas.

电刺激初级躯体感觉皮层和前额叶皮层（岛叶皮层）的外侧部分以及无颗粒皮层的外侧部分引起的下颌运动是特定的皮质位置刺激。 然而，刺激无颗粒皮质的内侧部分不会引起任何下颌运动。 这些皮质区发出直接投射到三叉神经感觉核复合体和三叉神经运动核周围的网状结构，这两者都包括兴奋性和/或抑制性前运动神经元。 这些结果可能表明，从大脑皮质区通过三叉神经前运动神经元向三叉神经运动核的几个间接投射参与了特征性下颌运动的诱导，下颌运动障碍是由于大脑皮质区间接投射系统的障碍。

项目成果

Projections to the trigeminal jaw-opening and jaw-closing premotoneurons in the nucleus of the solitary tract from the pharyngeal mucosa and the insular cortex in rats

大鼠咽粘膜和岛叶皮质孤束核中三叉神经开颌和闭颌前运动神经元的投影

• 发表时间: 2012
• 作者: A OKA;R TAKEDA;F SATO;F AKHTER;TL HAQUE;T KATO;H OHARA;Y-C BAE;K TAKADA;A YOSHIDA
• 通讯作者: A YOSHIDA

大脳皮質一次および二次体性感覚野から三叉神経感覚核への投射の差異の解明

阐明从大脑皮层的初级和次级体感区域到三叉神经感觉核的投射差异

• 发表时间: 2012
• 作者: Tahsinul Haque;Fatema Akhter;佐藤文彦;加藤隆史;岡綾香;Barry J Sessle;吉田篤
• 通讯作者: 吉田篤

Projections from the insular cortex to pain-receptive trigeminal caudal subnucleus (medullary dorsal horn) and other lower brainstem areas in rats

• DOI: 10.1016/j.neuroscience.2012.12.024
• 发表时间: 2013-03
• 期刊: Neuroscience
• 影响因子: 3.3
• 作者: F. Sato;F. Akhter;T. Haque;T. Kato;R. Takeda;Y. Nagase;B. Sessle;A. Yoshida

開口筋運動前ニューロンと閉口筋運動前ニューロンのラット孤束核内での機能局在

大鼠孤束核张口肌前运动神经元和闭口肌前运动神经元的功能定位。

• 发表时间: 2013
• 作者: 岡綾香;武田理恵子;大原春香;佐藤文彦;加藤隆史;山城隆;吉田篤
• 通讯作者: 吉田篤

Direct projections from the insular cortex to orofacial pain-related lower brainstem areas, especially to the trigeminal caudal subnucleus, in rats.

大鼠从岛叶皮质到口面部疼痛相关的下脑干区域的直接投射，特别是到三叉神经尾亚核的直接投射。

• 发表时间: 2012
• 作者: F Sato;F Akhter;T Haque;T Kato;R Takeda;K Higashiyama;Y-C Bae;A Yoshida
• 通讯作者: A Yoshida