Neuronal Mechanisms of Cerebral Cortex Controlling Trigeminal Mesencephalic Spindle Atfetents for Smooth Mastication

大脑皮层控制三叉神经中脑纺锤体平滑咀嚼的神经机制

• 批准号: 18592000
• 负责人: YOSHIDA Atsushi
• 金额: $ 2.53万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18592000/
• 关键词: brain; neuroscience; anatomy; dentistry; jaw movement; cortex

In subprimates, projections from the cerebral cortex to the trigeminal motor nucleus (Vmo) are considered to be not direct, but indirect through premotoneurons in the brainstem. However, the projection patterns of the corticofugal direct projections to the premotoneurons have not been examined well. Whereas, the premotoneurons for the Vmo include the mesencephalic nucleus (Vmes) neurons that are primary afferents whose cell bodies are located in the brain. Therefore the present study was conducted to examine the projection patterns morphologically in the rat. At first, we examined the distribution of the premotoneurons for the Vmo by making an injection of a retrograde tracer into the Vmo. The premotoneurons were found in the Vmes ipsilateral to the injection site, and in the trigeminal oral and principal nucleus, parabrachial nucleus, supratrigeminal nucleus, parvocellular reticular formation (pRF) surrounding the Vmo, and pRF medial to the trigeminal sensory nuclei bilaterally with an ipsilateral predominance to the injection site. Then, we examined the distribution of cortical neurons projecting directly to the premotoneurons for the Vmo, by making an injection of the retrograde tracer into the brainstem where the premotoneurons were labeled in the first experiment. The cortical neurons projecting to the reticular formation around the Vmo, the trigeminal oral nucleus, and the Vmes nucleus were found in the primary and secondary motor cortex, the primary somatosensory cortex, and the insular and limbic cortex, respectively.The present study demonstrated several, strong projections from the distinct cortical areas to the Vmo through premotoneurons including the Vmes neurons, which are topographically organized. The present study contributed to reveal complex neuronal mechanisms in the cortical control of jaw movements.

在亚灵长类动物中，从大脑皮质到三叉神经运动核(VMO)的投射被认为不是直接的，而是通过脑干中的前运动神经元间接的。然而，皮质分离神经元直接投射到前运动神经元的投射模式还没有得到很好的研究。然而，VMO的前运动神经元包括作为初级传入的中脑核(VME)神经元，其胞体位于脑内。因此，本研究对大鼠的投射模式进行了形态学研究。首先，我们通过向VMO内注入逆行示踪剂来观察VMO的前运动神经元的分布。前运动神经元分布于注射部位同侧的VME、三叉神经口侧和主核、臂旁核、三叉神经上核、VMO周围的小细胞网状结构(PRF)和两侧三叉神经感觉核内侧的PRF，注射部位以同侧为主。然后，我们通过在第一个实验中标记前运动神经元的脑干内注射逆行示踪剂，检查了直接投射到VMO前运动神经元的皮质神经元的分布。投射到VMO周围网状结构、三叉神经口腔核和VMEs核的皮质神经元分别位于初级和次级运动皮质、初级躯体感觉皮质以及岛叶和边缘皮质。本研究证实了从不同的皮质区域通过包括VMEs神经元在内的多个运动神经元向VMO投射的强烈投射。本研究有助于揭示皮质控制颌骨运动的复杂神经机制。

项目成果

モルモットの大脳皮質顎顔面口腔運動領域と視床との神経連絡

豚鼠大脑皮层、颌面部、口腔运动区和丘脑之间的神经连接

• 发表时间: 2007
• 作者: 磯貝 文彦;ほか
• 通讯作者: ほか

Nociceptive craniofacial muscle primary afferent neurons synapse in both the rostral and caudal brain stem

• DOI: 10.1152/jn.00990.2006
• 发表时间: 2007-07-01
• 期刊: JOURNAL OF NEUROPHYSIOLOGY
• 影响因子: 2.5
• 作者: Dessem, Dean;Moritani, Masayuki;Ambalavanar, Ranjinidevi
• 通讯作者: Ambalavanar, Ranjinidevi

Developmental changes in distribution of r-aminobutyric acid-and glycine-immunoreactive boutons on rat trigeminal motoneurons. I. Jaw-closing motoneurons.

大鼠三叉神经运动神经元上 r-氨基丁酸和甘氨酸免疫反应性布顿分布的发育变化。

• 发表时间: 2007
• 期刊: J Comp Neurol 503
• 作者: Paik SK;et. al.
• 通讯作者: et. al.

The distribution of excitatory and inhibitory synapses on single, reconstructed trigeminal motoneurons in the cat

猫单个重建三叉神经运动神经元上兴奋性和抑制性突触的分布

• 发表时间: 2006
• 作者: Shigenaga;Y.;Bae;Y C.;Moritani;M.;Yoshida;A
• 通讯作者: A

Developmental changes in distribution of y-aminobutyric acid-and glycine-immunoreactive boutons on rat trigeminal motoneurons. I. Jaw-closing motoneurons

大鼠三叉神经运动神经元上γ-氨基丁酸和甘氨酸免疫反应性布顿分布的发育变化。

• 发表时间: 2007
• 期刊: J. Comp. Neurol 503
• 作者: Paik;S K.;Bae;J Y.;Park;S E.;Moritani;M.;Yoshida;A.;Yeo;E J.;Choi;K S.;Ahn;D K.;Moon;C.;Shigenaga;Y.;Bae;Y C
• 通讯作者: Y C