Role of cystatin in stimulation of saliva flow and protection of oral mucosa

半胱氨酸蛋白酶抑制剂在刺激唾液流动和保护口腔粘膜中的作用

• 批准号: 23592948
• 负责人: NAKAGAWA Yoichi
• 金额: $ 3.24万
• 依托单位: Tsurumi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592948/
• 关键词: シェーグレン症候群; シスタチン; 唾液分泌; 生体防御

The cystatins are a family of cysteine protease inhibitors. Cysteine protease inhibitors are assumed to have important roles in apoptosis. Salivary cystatin decreased in Sjogren's syndrome patients, particularly cystatin S. In the labial salivary glands, intense staining of the cystatin was observed in the normal control group, but there were few positive examples in Sjogren's syndrome patients, and the staining was extremely low. These results suggest that the cystatin participates in the regulation of onset of Sjogren's syndrome.

半胱氨酸蛋白酶抑制剂是半胱氨酸蛋白酶抑制剂家族。半胱氨酸蛋白酶抑制剂被认为在细胞凋亡中具有重要作用。干燥综合征患者唾液胱抑素减少，尤其是胱抑素S。在唇唾液腺中，正常对照组可观察到强烈的胱抑素染色，但干燥综合征患者阳性例数很少，且染色极低。这些结果表明胱抑素参与调节干燥综合征的发作。