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Basic research about bone regeneration and oral implant for craniofacial defect patients

Basic research about bone regeneration and oral implant for craniofacial defect patients
颅面缺损患者骨再生及口腔种植基础研究
批准号:
23593054
负责人:
NAKAMURA Hiroshi
金额:
$3.24万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013

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中文摘要
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英文摘要
We generated systemic Ryk signal deficient mice. Ryk deficient mice exhibited a cleft palate and totally decrease of osteoclast number and osteoblast number in bone. Furthermore, we generated osteoclast-specific Ryk-deficient mice and osteoblast-specific Ryk-deficient mice. Interestingly, there are no cleft palate in both osteoclast-specific Ryk-deficient mice and osteoblast-specific Ryk-deficient mice. Osteoclast-specific Ryk-deficient mice have normal bone phenotype. These results suggest that Ryk expression in osteoclasts and osteoblasts is not essential for craniofacial defect.
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会议论文
BMP誘導性異所性骨形成における破骨細胞の役割
破骨细胞在 BMP 诱导异位骨形成中的作用
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [中村美どり]
通讯作者: 中村美どり
Stimulation of bone formation in cortical bone of mice treated with a receptor activator of nuclear factor-κB ligand (RANKL)-binding peptide that possesses osteoclastogenesis inhibitory activity.
用核因子 - κB配体(RANKL)结合肽的受体激活剂治疗的小鼠的皮质骨刺激骨形成,该肽具有破骨构成抑制活性。
DOI: 10.1074/jbc.m112.426080
发表时间: 2013-02-22
期刊: The Journal of biological chemistry
影响因子: --
作者: [Furuya Y, Inagaki A, Khan M, Mori K, Penninger JM, Nakamura M, Udagawa N, Aoki K, Ohya K, Uchida K, Yasuda H]
通讯作者: Yasuda H
BMP誘導性異所性骨における破骨細胞の役割
破骨细胞在 BMP 诱导异位骨中的作用
DOI: --
发表时间:
期刊:
影响因子: --
作者: [Yanagita M, Kojima Y, Mori K, Yamada S and Murakami S, 中村美どり]
通讯作者: 中村美どり
DOI: 10.5312/wjo.v3.i11.175
发表时间: 2012-11
期刊: World journal of orthopedics
影响因子: 1.9
作者: [T. Yamashita;N. Takahashi;N. Udagawa]
通讯作者: T. Yamashita;N. Takahashi;N. Udagawa
16
    Research on Data Resident Computing
    • 批准号:
      22650008
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.2万
    • 财政年份:
      2010
    • 负责人:
      NAKAMURA Hiroshi
    • 依托单位:
    Matrix metalloproteinase-3 in a stable form, a novel medicament for pulpitis
    • 批准号:
      21390512
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.56万
    • 财政年份:
      2009
    • 负责人:
      NAKAMURA Hiroshi
    • 依托单位:
    Study of Crude Bone Morphogenetic Protein(BMP)for use as Pulp-Capping Material
    • 批准号:
      18592103
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.07万
    • 财政年份:
      2006
    • 负责人:
      NAKAMURA Hiroshi
    • 依托单位:
    Architecture and Circuit-Level Co-Design for Low-Power High-Performance Microprocessor
    • 批准号:
      18200002
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $31.28万
    • 财政年份:
      2006
    • 负责人:
      NAKAMURA Hiroshi
    • 依托单位:
    海外基金