The elucidation of the impaired glucose tolerance mechanism to occur frequently in a thin youth woman

阐明瘦青年女性经常发生的糖耐量受损机制

• 批准号: 23617031
• 负责人: TSUKAHARA Takayoshi
• 金额: $ 3.16万
• 依托单位: Nagoya University of Arts and Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23617031/
• 关键词: 糖尿病; インクレチン; インスリン分泌; 食習慣; 耐糖能異常; やせ型; インクレチン分泌

We investigated the situation of impaired glucose tolerance (IGT) in young Japanese women and examined whether adoption of optimal carbohydrate intake could lead to improved IGT. We conducted a 75-g oral glucose tolerance test with 412 women enrolled at N University in Aichi Japan. IGT was found in 30.3% of the participants despite their young age. An open intervention study was conducted for 3 months with 26 of the women found to have IGT. The intervention was optimal carbohydrate intake based on body height 3 times per day.After the intervention, Glucagon-like peptide-1 level at 30 min and insulinogenic index was significantly increased, and plasma glucose level at 30 and 60 min and HbA1c were significantly decreased. These data suggest that the adoption of optimal carbohydrate intake could lead to increased insulin secretion and improve IGT in young women.

我们调查了日本年轻女性糖耐量受损（IGT）的情况，并研究了采用最佳碳水化合物摄入量是否可以改善IGT。我们对412名在日本爱知县N大学入学的女性进行了75克口服葡萄糖耐量试验。IGT被发现在30.3%的参与者，尽管他们的年轻。对26名IGT妇女进行了为期3个月的开放干预研究。干预后30 min胰高血糖素样肽-1水平和胰岛素生成指数显著升高，30 min和60 min血糖水平和HbA 1c显著降低。这些数据表明，采用最佳碳水化合物摄入量可能会导致胰岛素分泌增加，改善IGT的年轻女性。