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Development of immuno-gene therapy strategy using co-stimulatorymolecule linking local treatment and systemic anti-tumor effect.

Development of immuno-gene therapy strategy using co-stimulatorymolecule linking local treatment and systemic anti-tumor effect.
使用共刺激分子开发免疫基因治疗策略,将局部治疗和全身抗肿瘤作用联系起来。
批准号:
23791583
负责人:
SAITO Ryuta
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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中文摘要
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英文摘要
In this study, we confirmed that co-stimulatory molecule OX-40 plays pivotal role in inducing strong anti-tumor efficacy. Using OX-40 agonistic antibody, immunostimulatory effect was evaluated. Induction of anti-tumor effect was strongest when OX-40 signal was activated together with subcutaneous tumor vaccination. Thus, we tried to develop new immunotherapeutic strategy against glioblastoma. Activation of OX-40 signaling can be promising immunotherapy for glioblastoma.
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会议论文
DOI: 10.1007/s10014-012-0119-8
发表时间: 2013-07-01
期刊: BRAIN TUMOR PATHOLOGY
影响因子: 3.3
作者: [Kanamori, Masayuki, Kumabe, Toshihiro, Tominaga, Teiji]
通讯作者: Tominaga, Teiji
Metachronous, multicentric glioma of pilocytic astrocytoma with oligodendroglioma-like component and oligodendroglioma through distinct genetic aberrations
具有少突胶质细胞瘤样成分的毛细胞星形细胞瘤的异时性、多中心胶质瘤和通过不同遗传畸变的少突胶质细胞瘤
DOI: 10.3171/2012.9.jns112353
发表时间: 2013
期刊: J Neurosurg
影响因子: 4.1
作者: [Kanoke A,Kanamori M,Kumabe T,Saito R, 他2名]
通讯作者: 他2名
Pilomyxoid astrocytoma of the cerebellum with Williams syndrome
小脑 Pilomyxoid 星形细胞瘤伴 Williams 综合征
DOI: --
发表时间: 2013
期刊: Childs Nerv Syst
影响因子: --
作者: [Chonan M, Kanamori M, Kumabe T, Saito R, 他2名]
通讯作者: 他2名
Convection-enhanced delivery of nimustine hydrochloride (ACNU) for recurrent glioma patients
盐酸尼莫司汀 (ACNU) 的对流增强给药治疗复发性神经胶质瘤患者
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Saito R, 他5名]
通讯作者: 他5名
26
    Development of systemic antitumor effect against malignant glioma by local convection-enhanced delivery
    • 批准号:
      21791341
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.75万
    • 财政年份:
      2009
    • 负责人:
      SAITO Ryuta
    • 依托单位:
    海外基金