Identification of synovial sarcoma initiating cells

我们证明了细胞表面抗原A在滑膜肉瘤的球形亚群中高度表达，并与干性基因的表达相关。抗原A阳性细胞具有较高的致瘤性、自我更新性和再普及性；因此，我们认为抗原A可以丰富滑膜肉瘤的起始细胞。通过对42例滑膜肉瘤手术标本的免疫组化分析，抗原A的表达与预后不良密切相关。此外，抗原A特异性抑制剂能抑制滑膜肉瘤细胞系的体外增殖。本研究首次检测到滑膜肉瘤的起始细胞及其特异性标记物，对开发滑膜肉瘤的新疗法具有重要意义。

We demonstrated that the cell surface antigen A is highly expressed in the sphere forming subpopulation of synovial sarcoma and correlate with the expression of stemness genes. Antigen A positive cells possessed high tumorigenic, self-renewing, and re-popularizing activity; therefore we concluded that the Antigen A can enrich synovial sarcoma initiating cells. By immunohistochemical analysis of 42 synovial sarcoma surgical specimens, Antigen A expression was well correlated with poor prognosis. Moreover, the specific inhibitor of antigen A could suppress the proliferation of synovial sarcoma cell-lines in vitro.In this study, we first detect synovial sarcoma initiating cells and a specific marker, and these findings play a very important role about exploitation the new therapy against synovial sarcoma.