Characteristic changes of endothelial function in preeclampsia model rat by administration of nitric oxide synthase inhibitor

一氧化氮合酶抑制剂对子痫前期模型大鼠内皮功能的特征性改变

• 批准号: 23791848
• 负责人: YAMAMOTO Tamao
• 金额: $ 2.5万
• 依托单位: Nagoya City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791848/
• 关键词: 妊娠高血圧腎症; 血管内皮機能障害; 一酸化窒素; 活性酸素; 胎盤形成不全; 妊娠高血圧症候群

Preeclampsia is characterized as an increased peripheral vascular resistance. It is found that administration of the NOS inhibitor L-NAME at early pregnancy developed hypertension in rat similar to preeclampsia. Furthermore, we found action of endothelial nitric oxide (NO) was reduced due to possibly reactive oxygen species (ROS) in preeclamptic women. We investigated whether this administration modulates NO and ROS production in uterine artery endothelial cells at late pregnancy in rat.Blood pressure was higher and birth body weight was smaller in L-NAME-treated rats than in control rats. Trophoblast invasion was reduced in L-NAME-treated rats. ACh-induced endothelial NO production was higher, while endothelial cell ROS production and Ca increase was similar, in L-NAME-treated rats when compared with those in control rats. It is suggested that the increased endothelial NO production in uterine artery seen in L-NAME-treated rats may function to protect the development of hypertension.

先兆子痫的特征是外周血管阻力增加。研究发现，妊娠早期给予NOS抑制剂L-NAME后，大鼠会出现类似于先兆子痫的高血压。此外，我们发现先兆子痫女性的内皮一氧化氮（NO）作用可能由于活性氧（ROS）而降低。我们研究了这种给药是否调节大鼠妊娠晚期子宫动脉内皮细胞中 NO 和 ROS 的产生。与对照大鼠相比，L-NAME 治疗的大鼠血压较高，出生体重较小。 L-NAME 治疗大鼠的滋养层侵袭减少。与对照大鼠相比，L-NAME 治疗组大鼠中 ACh 诱导的内皮 NO 产生更高，而内皮细胞 ROS 产生和 Ca 增加相似。这表明，L-NAME 治疗大鼠子宫动脉中内皮 NO 产生的增加可能起到保护高血压发展的作用。

项目成果

The underlying mechanisms in reduced action of endothelial nitric oxide in resistance artery in preeclampsia

先兆子痫阻力动脉内皮一氧化氮作用减少的潜在机制

• 发表时间: 2013
• 作者: Suzuki Y;Yamamoto T
• 通讯作者: Yamamoto T

Oscillation of blood pressure seen in eclamptic women.

患有子痫的女性会出现血压波动。

• 发表时间: 2012
• 作者: Suzuki Y;Yamamoto T;Matsuura A
• 通讯作者: Matsuura A

子癇の治療.

治疗子痫。

• 发表时间: 2013
• 期刊: 血圧
• 作者: 鈴木佳克;松浦綾乃;山本珠生.
• 通讯作者: 山本珠生.

Characteristic changes in systemic blood pressure in eclampsia.

子痫全身血压的特征性变化。

• 发表时间: 2014
• 期刊: Hypertension Research in Pregnancy
• 影响因子: 0.2
• 作者: Kojima R;Matsuura A;Yamamoto T;Watanabe K;Suzuki Y.
• 通讯作者: Suzuki Y.

子癇の治療

子痫的治疗

• 发表时间: 2013
• 期刊: 血圧
• 作者: 築山尚史;三浦清徳;増崎英明;鈴木佳克,松浦綾乃,山本珠生
• 通讯作者: 鈴木佳克,松浦綾乃,山本珠生