Characteristic changes of endothelial function in preeclampsia model rat by administration of nitric oxide synthase inhibitor

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Preeclampsia is characterized as an increased peripheral vascular resistance. It is found that administration of the NOS inhibitor L-NAME at early pregnancy developed hypertension in rat similar to preeclampsia. Furthermore, we found action of endothelial nitric oxide (NO) was reduced due to possibly reactive oxygen species (ROS) in preeclamptic women. We investigated whether this administration modulates NO and ROS production in uterine artery endothelial cells at late pregnancy in rat.Blood pressure was higher and birth body weight was smaller in L-NAME-treated rats than in control rats. Trophoblast invasion was reduced in L-NAME-treated rats. ACh-induced endothelial NO production was higher, while endothelial cell ROS production and Ca increase was similar, in L-NAME-treated rats when compared with those in control rats. It is suggested that the increased endothelial NO production in uterine artery seen in L-NAME-treated rats may function to protect the development of hypertension.