Characteristic changes in endothelial function by administration of NO synthase inhibitor during placental formation

研究发现，在妊娠早期给予一氧化氮合酶抑制剂L-NAME可引起大鼠高血压。与生理盐水治疗组相比，L治疗组大鼠血压升高，而出生体重减轻。乙酰胆碱(ACh)诱导的子宫动脉内皮细胞一氧化氮(NO)的产生较高，尽管ACh诱导的活性氧产生与L治疗的大鼠相似。提示L-NAME可增加子宫动脉内皮细胞NO的生成，对血管内皮细胞高血压有保护作用。

It is found that administration of the NOS inhibitor L-NAME at early pregnancy developed hypertension in rat. Blood pressure was increasing, while birth body weight was smaller in L-NAME-treated rats than in saline-treated rats. Acetylcholine (ACh)-induced endothelial nitric oxide (NO) production in uterine artery was higher, although ACh-induced reactive oxygen species production was similar in L-NAME-treated rats. It is suggested that the increased endothelial NO production in uterine artery by administration of L-NAME may protect the development of hypertension in endothelium.