Analysis on roles of immune modulating cytokines for strategic development of molecular therapeutics for age-related macular degeneration

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We analyzed the relationship between the levels of intraocular inflammatory cytokines and polypoidal choroidal vasculopathy (PCV), a major form of age related macular degeneration (ARMD), and found a significantly high risk was provided by elevation of IL-23, VEGF, and IL-4. To further understand molecular pathology of choroidal neovascularization (CNV), we also analyzed cytokine levels of myopic CNV patients. IL-10 provided a significantly high risk for myopic CNV. To understand inflammatory aspect of CNV, murine laser induced choroidal neovascularization model was used. Currently, our analysis on the mouse CNV model has identified the candidate target signaling molecule for ARMD using analysis of transgenic mouse strains for signaling of the molecule