Apoptotic cell engulfment by cancer cells

凋亡细胞被癌细胞吞噬

• 批准号: 23792099
• 负责人: YAMAZAKI Manabu
• 金额: $ 2.75万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23792099/
• 关键词: 癌; 病理学; アポトーシス; 細胞・組織; 貪食; 口腔癌; MFG-E8

Apoptotic oral squamous cell carcinoma (SCC) cells are engulfed not only by macrophages but also by neighboring SCC cells, which could be a potential anti-cancer avenue. Since apoptotic SCC cells were immunohistochemically positive for milk fat globule-epidermal growth factor-factor 8 (MFG-E8), one of the phagocytosis regulating molecules, apoptotic SCC cells were suggested to be removed by the MFG-E8-related phagocytotic pathways. In addition, MFG-E8 was simultaneously expressed in SCC cells forming small foci at the invading front, and its expression levels in SCC cells in culture were correlated with cell growth, anti-apoptotic activity and invasion. The results indicated that the apoptotic cell clearance via MFG-E8 produced by cancer cells enhances aggressiveness of cancer cell behaviors.

凋亡的口腔鳞状细胞癌（SCC）细胞不仅被巨噬细胞吞噬，而且被邻近的SCC细胞吞噬，这可能是一种潜在的抗癌途径。由于凋亡的SCC细胞免疫组化检测乳脂球-表皮生长因子-因子8 （MFG-E8）阳性，提示凋亡的SCC细胞可能通过MFG-E8相关的吞噬途径被清除。此外，MFG-E8在侵袭前沿形成小灶的SCC细胞中同时表达，其在培养SCC细胞中的表达水平与细胞生长、抗凋亡活性和侵袭相关。结果表明，癌细胞通过MFG-E8清除凋亡细胞，增强了癌细胞行为的侵袭性。

项目成果

Podoplanin is a novel myoepithelial cell marker in pleomorphic adenoma and other salivary gland tumors with myoepithelial differentiation

Podoplanin 是多形性腺瘤和其他具有肌上皮分化的唾液腺肿瘤中的新型肌上皮细胞标记物

• 发表时间: 2013
• 期刊: Virchows Archiv
• 影响因子: 3.5
• 作者: Tsuneki M;Maruyama S;Yamazaki M;Essa A;Abe T;Babkair HA;Ahsan MS;Cheng J;Saku
• 通讯作者: Saku

Podoplanin expression profiles characteristic of odontogenic tumor-specific tissue architectures

• DOI: 10.1016/j.prp.2011.12.016
• 发表时间: 2012-01-01
• 期刊: PATHOLOGY RESEARCH AND PRACTICE
• 影响因子: 2.8
• 作者: Tsuneki, Masayuki;Maruyama, Satoshi;Saku, Takashi
• 通讯作者: Saku, Takashi

口腔扁平上皮癌におけるMFG-E8の発現:腫瘍進展とアポトーシス細胞処理への関与

MFG-E8 在口腔鳞状细胞癌中的表达：参与肿瘤进展和凋亡细胞处理

• 发表时间: 2011
• 作者: Ahsan MS;Yamazaki M;Maruyama S;Kobayashi T;Ida-Yonemochi H;Hasegawa M;Adeola HA;Cheng J;Saku T.;山崎学;山崎 学;山崎学,丸山智,程〓,朔敬;山崎学,丸山智,程〓,藤田一,高木律男,林孝文,朔敬;山崎学,丸山智,程〓,朔敬
• 通讯作者: 山崎学,丸山智,程〓,朔敬

Parenchymal-stromal switching for extracellular matrix production on invasion of oral squamous cell carcinoma

口腔鳞状细胞癌侵袭时细胞外基质产生的实质-基质转换

• DOI: 10.1016/j.humpath.2012.02.006
• 发表时间: 2012
• 期刊: Human Pathology
• 影响因子: 3.3
• 作者: Metwaly H;Maruyama S;Yamazaki M;Tsuneki M;Abe T;Jen KY;Cheng J;Saku T.
• 通讯作者: Saku T.

Loss of keratin 13 in oral carcinoma in situ: a comparative study of protein and gene expression levels using paraffin sections

口腔原位癌中角蛋白 13 的丢失：使用石蜡切片进行蛋白质和基因表达水平的比较研究

• DOI: 10.1111/j.1365-2559.2010.03732.x
• 发表时间: 2012
• 期刊: Mod Pathol
• 作者: Ida-Yonemochi H;Maruyama S;Kobayashi T;Yamazaki M;Cheng J;Saku T
• 通讯作者: Saku T