Development of the effective bone augmentation using intracellular transfection of anti-apoptosis protein HSP27

在本研究中，我们探讨了抗凋亡蛋白HSP27在移植细胞中的应用，以探索细胞移植骨增强的新途径。过表达HSP27不影响成骨细胞的增殖和矿化能力，但过表达HSP27可减少成骨细胞的凋亡。此外，在细胞移植初期，移植细胞凋亡也受到抑制，表达增殖标志物的细胞增多。

In the present study, to explore a new way of cell transplantation for bone augmentation, we evaluate the application of HSP27, an anti-apoptotic protein to the transplanted cell. The over expression of HSP27 did not affect the cell proliferation and mineralization ability of osteoblast, however, apoptosis was diminished by the over expression of HSP27. Furthermore, transplanted cell apoptosis was also inhibited and proliferation marker expressing cells were increased at the initial stage of cell transplantation.