Molecular genetic investigation of size of mandibular angle in consomic mice

本研究的目的是利用不同大小的下颌角小鼠的DNA来鉴定含有下颌角大小的候选致病基因的染色体。利用C3H和B6品系中具有多态性的DNA标记，进行了连锁分析和数量性状座位分析。提示携带下颌角致病基因的候选染色体与D13Mit76连锁。此外，还测量了小鼠下颌角，推测13号染色体与调控有关。此外，本研究的目的是阐明环境因素对颌骨随时间的影响。使用Micro-CT扫描5周龄时拔除所有上颌磨牙并饲喂粉状饲料的大鼠的头部，并观察持续20周的颌骨形态变化。拔牙组术后7~20周下颌角明显增大。

The aim of this study was to identify the chromosomes harboring candidate causative genes for size of mandibular angle using DNA from mice with different size of mandibular angle. Using DNA markers with polymorphisms in the C3H and B6 strains, linkage analysis and quantitative trait locus analysis were conducted. This suggests that the candidate chromosomes harboring causative genes for mandibular angle are linked with D13Mit76. Furthermore consomic mice mandibular angle were measured, it was suggested that the No.13 chromosome is concerned with regulation.Furthermore the objective of this study was to elucidate the influence by an environmental factor on the jawbone over time. Micro-CT was used to scan the heads of rats that underwent extraction of all maxillary molars at age 5 weeks and were reared on a powdered diet, and changes in jawbone morphology up to 20 weeks were investigated. In the extraction group, mandibular angle was significantly larger from 7 weeks to 20 weeks.