Molecular genetic investigation of size of mandibular angle in consomic mice

体鼠下颌角大小的分子遗传学研究

• 批准号: 23792450
• 负责人: OGAWA kei
• 金额: $ 1.25万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23792450/
• 关键词: 下顎角の大きさ; マウス; ラット; 遺伝子; micro-CT; 下顎骨; 下顎角; 近郊系マウス; コンソミックマウス; 近交系マウス

The aim of this study was to identify the chromosomes harboring candidate causative genes for size of mandibular angle using DNA from mice with different size of mandibular angle. Using DNA markers with polymorphisms in the C3H and B6 strains, linkage analysis and quantitative trait locus analysis were conducted. This suggests that the candidate chromosomes harboring causative genes for mandibular angle are linked with D13Mit76. Furthermore consomic mice mandibular angle were measured, it was suggested that the No.13 chromosome is concerned with regulation.Furthermore the objective of this study was to elucidate the influence by an environmental factor on the jawbone over time. Micro-CT was used to scan the heads of rats that underwent extraction of all maxillary molars at age 5 weeks and were reared on a powdered diet, and changes in jawbone morphology up to 20 weeks were investigated. In the extraction group, mandibular angle was significantly larger from 7 weeks to 20 weeks.

本研究的目的是利用不同下颌角大小的小鼠DNA，寻找携带下颌角大小候选致病基因的染色体。利用在C3 H和B6品系中具有多态性的DNA标记，进行了连锁分析和数量性状位点分析。提示下颌角致病基因的候选染色体与D13 Mit 76连锁。此外，还对正常小鼠下颌角进行了测量，结果表明13号染色体可能与下颌角的调控有关，本研究的目的是进一步阐明环境因素对下颌角随时间变化的影响。Micro-CT被用来扫描大鼠的头部，这些大鼠在5周龄时拔除了所有的上颌磨牙，并以粉末状饮食饲养，并研究了20周内颌骨形态的变化。拔牙组7 ~ 20周下颌角明显增大。

项目成果

上顎臼歯抜歯および粉末飼料がラット顎骨に及ぼす影響

拔上磨牙和粉状饲料对大鼠颌骨的影响

• 发表时间: 2012
• 作者: Deng X;Oguri S;Funayama H;Ohtaki Y;Ohsako M;Yu Z;Sugawara S;Endo Y.;Atsushi Arai;小川京,張渓,阿保憲興,前田隆秀
• 通讯作者: 小川京,張渓,阿保憲興,前田隆秀

上顎臼歯抜歯および粉状飼料がラット顎骨に及ぼす影響の検討

拔除上颌磨牙和粉状饲料对大鼠颌骨影响的研究

• 发表时间: 2012
• 作者: 小川京;張渓;阿保憲興;前田隆秀
• 通讯作者: 前田隆秀

Effects of mastication dysfunction in parental rats and progeny

咀嚼功能障碍对亲代大鼠及其子代的影响

• 发表时间: 2012
• 作者: Kei Ogawa;Xi Zhang;Hisayoshi Muramatsu;Takahide Maeda
• 通讯作者: Takahide Maeda

上顎臼歯抜歯および粉末飼料下にて継代飼育したラットにおける顎骨への影響

拔除上颌磨牙并传代粉状饲料对大鼠颌骨的影响

• 发表时间: 2013
• 作者: Miyake S.;Wada-Takahashi S.;Honda H.;Takahashi SS.;Sasaguri K.;Sato S.;Lee M-C.;小川京,柴崎兼次,山本晴子,清水武彦,前田隆秀
• 通讯作者: 小川京,柴崎兼次,山本晴子,清水武彦,前田隆秀

Effects of mastication dysfunction in parental rats and progeny X

咀嚼功能障碍对亲代大鼠及其子代 X 的影响

• 发表时间: 2012
• 作者: ZHANG;K. OGAWA;T. MAEDA
• 通讯作者: T. MAEDA