Molecular genetic investigation of size of mandibular angle in consomic mice

本研究的目的是利用不同下颌骨角大小小鼠的DNA，鉴定含有下颌骨角大小候选致病基因的染色体。利用C3H和B6菌株的多态性DNA标记，进行连锁分析和数量性状位点分析。这表明含有下颌角致病基因的候选染色体与D13Mit76有关。同时测定了经济小鼠的下颌角，提示13号染色体参与了下颌角的调节。此外，本研究的目的是阐明环境因素对颌骨的影响随着时间的推移。采用Micro-CT对5周龄拔除全部上颌磨牙的大鼠头部进行扫描，观察20周龄前颌骨形态的变化。拔牙组7 ~ 20周下颌角明显增大。

The aim of this study was to identify the chromosomes harboring candidate causative genes for size of mandibular angle using DNA from mice with different size of mandibular angle. Using DNA markers with polymorphisms in the C3H and B6 strains, linkage analysis and quantitative trait locus analysis were conducted. This suggests that the candidate chromosomes harboring causative genes for mandibular angle are linked with D13Mit76. Furthermore consomic mice mandibular angle were measured, it was suggested that the No.13 chromosome is concerned with regulation.Furthermore the objective of this study was to elucidate the influence by an environmental factor on the jawbone over time. Micro-CT was used to scan the heads of rats that underwent extraction of all maxillary molars at age 5 weeks and were reared on a powdered diet, and changes in jawbone morphology up to 20 weeks were investigated. In the extraction group, mandibular angle was significantly larger from 7 weeks to 20 weeks.