Study towards nitrene transfer reaction using azide based on design of new iron catalyst

基于新型铁催化剂设计的叠氮化物氮烯转移反应研究

• 批准号: 23750116
• 负责人: EGAMI Hiromichi
• 金额: $ 2.75万
• 依托单位: The Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23750116/
• 关键词: 二核錯体; 触媒; 鉄; 銅; 酸化反応; 酸化的官能基化反応; 触媒設計; 遷移金属; ナイトレン; アジド

A synthetic method for a new series of ligands, which were designed based on a working hypothesis, has been established as originally planned, and some metal complexes were prepared. Although an efficient catalyst for a nitrene transfer reaction using azide as a nitrene source could not be found at this moment, it was found that some complexes worked as catalysts for aerobic oxidation during this study. On the other hand, a new method for oxidative introduction of an amine functionality into olefins was established.

根据工作假设设计的一系列新配体的合成方法已按原计划建立，并制备了一些金属配合物。虽然目前还没有找到一种有效的以叠氮化物为氮宾源的氮宾转移反应催化剂，但在本研究中发现一些配合物可以作为有氧氧化的催化剂。另一方面，建立了一种将胺官能团氧化引入烯烃的新方法。

项目成果

Rapid Trifluoromethylation of Indole Derivatives

• DOI: 10.3987/com-12-s(n)101
• 发表时间: 2012
• 期刊: Heterocycles
• 影响因子: 0.6
• 作者: M. Sodeoka;Aya Miyazaki;R. Shimizu;H. Egami

Oxytrifluoromethylation of multiple bonds using copper catalyst under mild conditions

• DOI: 10.1016/j.tetlet.2012.07.134
• 发表时间: 2012-10-10
• 期刊: TETRAHEDRON LETTERS
• 影响因子: 1.8
• 作者: Egami, Hiromichi;Shimizu, Ryo;Sodeoka, Mikiko
• 通讯作者: Sodeoka, Mikiko

アリルシランのトリフルオロメチル化反応

烯丙基硅烷的三氟甲基化反应

• 发表时间: 2012
• 作者: 清水怜;江上寛通;濱島義隆;袖岡幹子
• 通讯作者: 袖岡幹子

炭素-炭素結合形成を伴うオレフィン類のトリフルオロメチル化反応

烯烃形成碳-碳键的三氟甲基化反应

• 发表时间: 2013
• 作者: 江上寛通;清水怜;河村伸太郎;袖岡幹子
• 通讯作者: 袖岡幹子

Concise synthesis of oxindole derivatives bearing a 3-trifluoroethyl group: Copper-catalyzed trifluoromethylation of acryloanilides

• DOI: 10.1016/j.jfluchem.2013.03.009
• 发表时间: 2013-08-01
• 期刊: JOURNAL OF FLUORINE CHEMISTRY
• 影响因子: 1.9
• 作者: Egami, Hiromichi;Shimizu, Ryo;Sodeoka, Mikiko
• 通讯作者: Sodeoka, Mikiko