Functional analysis of Jmjd5, a candidate cancer-related geneidentified by retroviral insertional mutagenesis

逆转录病毒插入突变鉴定的候选癌症相关基因 Jmjd5 的功能分析

• 批准号: 23790220
• 负责人: ISHIMURA Akihiko
• 金额: $ 2.75万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790220/
• 关键词: 遺伝子発現; 発生・分化; 細胞増殖; 癌; がん; ヒストンメチル化修飾; マウス胚発生

Our retroviral insertional mutagenesis in mice showed frequent identification of JmjC family genes as novel candidates cancer-related genes. Jmjd5, one of the family genes, was also a target for the retrovirus, and we generated Jmjd5-deficientmice (Jmjd5△囗△) to investigate the physiological role of Jmjd5. We showed that Jmjd5 was involved in embryonic cell proliferation by fine-tuning the expression of p21 (Ishimura et al., Development 2012).

Our retroviral insertional mutagenesis in mice showed frequent identification of JmjC family genes as novel candidates cancer-related genes. Jmjd5, one of the family genes, was also a target for the retrovirus, and we generated Jmjd5-deficientmice (Jmjd5△囗△) to investigate the physiological role of Jmjd5. We showed that Jmjd5 was involved in embryonic cell proliferation by fine-tuning the expression of p21 (Ishimura et al. al., Development 2012).

项目成果

Jmjd5, an H3K36me2 histone demethylase, modulates embryonic cell proliferation through the regulation of Cdkn1a expression

• DOI: 10.1242/dev.074138
• 发表时间: 2012-02-15
• 期刊: DEVELOPMENT
• 影响因子: 4.6
• 作者: Ishimura, Akihiko;Minehata, Ken-ichi;Suzuki, Takeshi
• 通讯作者: Suzuki, Takeshi

PLU1 histone demethylase decreases the expression of KAT5 and enhances the invasive activity of the cells

PLU1组蛋白去甲基化酶降低KAT5的表达并增强细胞的侵袭活性

• DOI: 10.1042/bj20110343
• 发表时间: 2011
• 期刊: Biochemical J.
• 作者: Yoshida M;Ishimura A;Terashima M;Enkhbaatar Z;Nozaki N;Satou K;Suzuki T
• 通讯作者: Suzuki T

Jmjd5, a candidate cancere-related gene identified by retroviral insertional mutagenesis, regulates the expression of Cdkn1a and modulates embryonic cell proliferation

Jmjd5 是通过逆转录病毒插入诱变鉴定的候选癌症相关基因，调节 Cdkn1a 的表达并调节胚胎细胞增殖

• 发表时间: 2011
• 作者: Ishimura A;Minehata K;Terashima M;Hara T and Suzuki T
• 通讯作者: Hara T and Suzuki T

Jmjd5, a JmjC domain containing protein, modulates embryonic cell proliferation through the regulation of p53-target genes expression.

Jmjd5 是一种含有 JmjC 结构域的蛋白质，通过调节 p53 靶基因的表达来调节胚胎细胞增殖。

• 作者: Ishimura A;Minehata K;Terashima M;Hara T and Suzuki T;宝田 美佳;Ishimura A
• 通讯作者: Ishimura A