Functional analysis of Jmjd5, a candidate cancer-related geneidentified by retroviral insertional mutagenesis
Functional analysis of Jmjd5, a candidate cancer-related geneidentified by retroviral insertional mutagenesis
批准号:
23790220
负责人:
ISHIMURA Akihiko
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
Our retroviral insertional mutagenesis in mice showed frequent identification of JmjC family genes as novel candidates cancer-related genes. Jmjd5, one of the family genes, was also a target for the retrovirus, and we generated Jmjd5-deficientmice (Jmjd5△囗△) to investigate the physiological role of Jmjd5. We showed that Jmjd5 was involved in embryonic cell proliferation by fine-tuning the expression of p21 (Ishimura et al., Development 2012).
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DOI:
10.1242/dev.074138
发表时间:
2012-02-15
期刊:
DEVELOPMENT
影响因子:
4.6
作者:
[Ishimura, Akihiko, Minehata, Ken-ichi, Suzuki, Takeshi]
通讯作者:
Suzuki, Takeshi
PLU1 histone demethylase decreases the expression of KAT5 and enhances the invasive activity of the cells
PLU1组蛋白去甲基化酶降低KAT5的表达并增强细胞的侵袭活性
DOI:
10.1042/bj20110343
发表时间:
2011
期刊:
Biochemical J.
影响因子:
--
作者:
[Yoshida M, Ishimura A, Terashima M, Enkhbaatar Z, Nozaki N, Satou K, Suzuki T]
通讯作者:
Suzuki T
Jmjd5, a candidate cancere-related gene identified by retroviral insertional mutagenesis, regulates the expression of Cdkn1a and modulates embryonic cell proliferation
Jmjd5 是通过逆转录病毒插入诱变鉴定的候选癌症相关基因,调节 Cdkn1a 的表达并调节胚胎细胞增殖
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Ishimura A, Minehata K, Terashima M, Hara T and Suzuki T]
通讯作者:
Hara T and Suzuki T
Jmjd5, a JmjC domain containing protein, modulates embryonic cell proliferation through the regulation of p53-target genes expression.
Jmjd5 是一种含有 JmjC 结构域的蛋白质,通过调节 p53 靶基因的表达来调节胚胎细胞增殖。
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[Ishimura A, Minehata K, Terashima M, Hara T and Suzuki T, 宝田 美佳, Ishimura A]
通讯作者:
Ishimura A
Functional analysis of Jmjd5, a candidate tumor suppressor gene, for angiogenesis, hematopoiesis and tumorigenesis.
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批准号:21790178
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.75万
-
财政年份:2009
-
负责人:ISHIMURA Akihiko
-
依托单位:
A role of Man1, an inner nuclear membrane protein, in left-right axis formation
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批准号:19790147
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项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.32万
-
财政年份:2007
-
负责人:ISHIMURA Akihiko
-
依托单位:
海外基金