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Functional analysis of Jmjd5, a candidate cancer-related geneidentified by retroviral insertional mutagenesis

Functional analysis of Jmjd5, a candidate cancer-related geneidentified by retroviral insertional mutagenesis
逆转录病毒插入突变鉴定的候选癌症相关基因 Jmjd5 的功能分析
批准号:
23790220
负责人:
ISHIMURA Akihiko
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012

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中文摘要
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英文摘要
Our retroviral insertional mutagenesis in mice showed frequent identification of JmjC family genes as novel candidates cancer-related genes. Jmjd5, one of the family genes, was also a target for the retrovirus, and we generated Jmjd5-deficientmice (Jmjd5△囗△) to investigate the physiological role of Jmjd5. We showed that Jmjd5 was involved in embryonic cell proliferation by fine-tuning the expression of p21 (Ishimura et al., Development 2012).
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DOI: 10.1242/dev.074138
发表时间: 2012-02-15
期刊: DEVELOPMENT
影响因子: 4.6
作者: [Ishimura, Akihiko, Minehata, Ken-ichi, Suzuki, Takeshi]
通讯作者: Suzuki, Takeshi
PLU1 histone demethylase decreases the expression of KAT5 and enhances the invasive activity of the cells
PLU1组蛋白去甲基化酶降低KAT5的表达并增强细胞的侵袭活性
DOI: 10.1042/bj20110343
发表时间: 2011
期刊: Biochemical J.
影响因子: --
作者: [Yoshida M, Ishimura A, Terashima M, Enkhbaatar Z, Nozaki N, Satou K, Suzuki T]
通讯作者: Suzuki T
Jmjd5, a candidate cancere-related gene identified by retroviral insertional mutagenesis, regulates the expression of Cdkn1a and modulates embryonic cell proliferation
Jmjd5 是通过逆转录病毒插入诱变鉴定的候选癌症相关基因,调节 Cdkn1a 的表达并调节胚胎细胞增殖
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Ishimura A, Minehata K, Terashima M, Hara T and Suzuki T]
通讯作者: Hara T and Suzuki T
Jmjd5, a JmjC domain containing protein, modulates embryonic cell proliferation through the regulation of p53-target genes expression.
Jmjd5 是一种含有 JmjC 结构域的蛋白质,通过调节 p53 靶基因的表达来调节胚胎细胞增殖。
DOI: --
发表时间:
期刊:
影响因子: --
作者: [Ishimura A, Minehata K, Terashima M, Hara T and Suzuki T, 宝田 美佳, Ishimura A]
通讯作者: Ishimura A
Functional analysis of Jmjd5, a candidate tumor suppressor gene, for angiogenesis, hematopoiesis and tumorigenesis.
  • 批准号:
    21790178
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
  • 资助金额:
    $2.75万
  • 财政年份:
    2009
  • 负责人:
    ISHIMURA Akihiko
  • 依托单位:
A role of Man1, an inner nuclear membrane protein, in left-right axis formation
  • 批准号:
    19790147
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
  • 资助金额:
    $2.32万
  • 财政年份:
    2007
  • 负责人:
    ISHIMURA Akihiko
  • 依托单位:
海外基金