Functional analysis of Jmjd5, a candidate tumor suppressor gene, for angiogenesis, hematopoiesis and tumorigenesis.
Functional analysis of Jmjd5, a candidate tumor suppressor gene, for angiogenesis, hematopoiesis and tumorigenesis.
批准号:
21790178
负责人:
ISHIMURA Akihiko
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
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英文摘要
In order to identify novel cancer-related genes, we have performed the retroviral insertional mutagenesis in mice, resulting in identification of Jmjd5, a histone demethylase. In this study, we have generated Jmjd5-deficient mice to investigate in vivo role of Jmjd5. Our results showed that Jmjd5 was involved in embryonic cell proliferation and that Cdkn1a might be one of Jmjd5 targets.
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The physiological role of Jmjd5, a candidate cancer gene identified by retroviral insertional mutagenesis.
Jmjd5 的生理作用,Jmjd5 是通过逆转录病毒插入突变鉴定的候选癌症基因。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Ishimura A., Minehata K., Terashima M., Hara T., Suzuki T.]
通讯作者:
Suzuki T.
The physiological function of Jmjd5, a candidate cancer-related gene identified by retroviral insertional mutagenesis.
Jmjd5 的生理功能,这是通过逆转录病毒插入突变鉴定的候选癌症相关基因。
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Ishimura A, Minehata K, Terashima M, Hara T, Suzuki T.]
通讯作者:
Suzuki T.
The role of Jmjd5, a candidate cancer gene identified by retroviral insertional mutagenesis : Analysis of Jmjd5-deficient mice.
Jmjd5(通过逆转录病毒插入诱变鉴定的候选癌症基因)的作用:Jmjd5 缺陷小鼠的分析。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Ishimura A., Minehata K., Terashima M., Hara T., Suzuki T.]
通讯作者:
Suzuki T.
Functional analysis of Jmjd5, a candidate cancer gene identified by retroviral insertional mutagenesis.
Jmjd5 的功能分析,Jmjd5 是通过逆转录病毒插入突变鉴定的候选癌症基因。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Ishimura A., Minehata K., Terashima M., Hara T., Suzuki T.]
通讯作者:
Suzuki T.
DOI:
10.1016/j.bbrc.2010.07.061
发表时间:
2010-08
期刊:
Biochemical and biophysical research communications
影响因子:
3.1
作者:
[Minoru Terashima;A. Ishimura;Masakazu Yoshida;Yutaka Suzuki;S. Sugano;Takeshisa Suzuki]
通讯作者:
Minoru Terashima;A. Ishimura;Masakazu Yoshida;Yutaka Suzuki;S. Sugano;Takeshisa Suzuki
共 8 条
Functional analysis of Jmjd5, a candidate cancer-related geneidentified by retroviral insertional mutagenesis
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批准号:23790220
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.75万
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财政年份:2011
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负责人:ISHIMURA Akihiko
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依托单位:
A role of Man1, an inner nuclear membrane protein, in left-right axis formation
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批准号:19790147
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.32万
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财政年份:2007
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负责人:ISHIMURA Akihiko
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依托单位:
海外基金