Role of circadian clocks in allergic asthma

生物钟在过敏性哮喘中的作用

• 批准号: 23790904
• 负责人: NAKAMURA Yuki
• 金额: $ 2.66万
• 依托单位: University of Yamanashi
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23790904/
• 关键词: 体内時計; 樹状細胞; 喘息; マスト細胞

The purpose of this research is to solve the role which the biological clock plays in development of symptoms and condition revelation of allergic asthma and to advocate the new approach to prevention/medical treatment of the allergic asthma by circadian clocks control. In the wild-type mouse, the difference in condition was accepted by carrying out sensitization to different time. However, the difference in condition was not accepted in Clock, a key clock gene, mutant mouse. In addition, it foundout that revelation of Toll-like receptor (TLR) 4 on wild-type mice origin bone marrow-derived dendritic cell (BMDC) was controlled by a biological clock. These results suggest that the onset of allergic asthma was dependent on circadian change of TLR4 on dendritic cells controlled by the circadian clock.

本研究的目的是解决生物钟在过敏性哮喘的症状发展和病情揭示中的作用，倡导通过昼夜节律控制来防治过敏性哮喘的新途径。在野生型小鼠中，通过对不同时间进行致敏来接受条件的差异。然而，在关键时钟基因Clock突变小鼠中，条件的差异是不被接受的。此外，还发现Toll样受体(TLR)4在野生型小鼠骨髓来源的树突状细胞(BMDC)上的表达受生物钟控制。这些结果表明，过敏性哮喘的发生依赖于昼夜节律控制的树突状细胞上TLR4的昼夜变化。

项目成果

マスト細胞の内在時計による即時型皮膚反応の日内変動の調節

肥大细胞内部时钟调节即时皮肤反应的昼夜波动

• 发表时间: 2012
• 作者: Okada;Y.;K. Oh-oka;Y. Nakamura;K. Ishimaru;S. Matsuoka;K. Okumura;H. Ogawa;M. Hisamoto;T. Okuda;and A. Nakao;黒沼 幸治;藤澤朋幸，飯野和美，橋本大，須田隆文，千田金吾，前川真人;坂本憲穂;中村勇規,中尾篤人,柴田重信
• 通讯作者: 中村勇規,中尾篤人,柴田重信

Dietary resveratrol prevents the development of food allergy in mice.

• DOI: 10.1371/journal.pone.0044338
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Okada Y;Oh-oka K;Nakamura Y;Ishimaru K;Matsuoka S;Okumura K;Ogawa H;Hisamoto M;Okuda T;Nakao A
• 通讯作者: Nakao A

山梨大学医学部免疫学講座

山梨大学医学部免疫学系

山梨大学 研究者総覧

山梨大学研究员名单

Endogenous TGF‐β activity limits TSLP expression in the intervertebral disc tissue by suppressing NF‐κB activation

• DOI: 10.1002/jor.22337
• 发表时间: 2013-07
• 期刊: Journal of Orthopaedic Research
• 影响因子: 2.8
• 作者: Yong-Ming Zhu;Tetsuro Ohba;Takashi Ando;Koji Fujita;Kensuke Koyama;Yuki Nakamura;R. Katoh,;H. Haro;A. Nakao