Regulations of hematopoietic stem cell system by the control ofintracellular ATP
Regulations of hematopoietic stem cell system by the control ofintracellular ATP
批准号:
23791076
负责人:
TADOKORO Yuko
金额:
$2.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
Many tissue specific stem cells stay dormant. Therefore, the regulation of intracellular ATP is important for the control of the longevity or behaviors of stem cells. The LKB1-AMPK signaling functions as an intracellular energy sensor. To examine the role of LKB1 or AMPK in the regulatory system of hematopoietic stem cell, I analyzed LKB1- or AMPK-deficient hematopoietic stem cells. Our data demonstrated that LKB1 and AMPK contributed to the maintenance of hematopoietic stem cells.
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DOI:
--
发表时间:
2011
期刊:
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DOI:
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发表时间:
2011
期刊:
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发表时间:
2011
期刊:
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发表时间:
2012
期刊:
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海外基金