Regulations of hematopoietic stem cell system by the control ofintracellular ATP

许多组织特异性干细胞处于休眠状态。因此，细胞内ATP的调控对于控制干细胞的寿命或行为具有重要意义。LKB1-AMPK信号作为细胞内能量传感器起作用。为了研究LKB1或AMPK在造血干细胞调控系统中的作用，我分析了LKB1或AMPK缺陷的造血干细胞。我们的数据表明，LKB1和AMPK有助于维持造血干细胞。

Many tissue specific stem cells stay dormant. Therefore, the regulation of intracellular ATP is important for the control of the longevity or behaviors of stem cells. The LKB1-AMPK signaling functions as an intracellular energy sensor. To examine the role of LKB1 or AMPK in the regulatory system of hematopoietic stem cell, I analyzed LKB1- or AMPK-deficient hematopoietic stem cells. Our data demonstrated that LKB1 and AMPK contributed to the maintenance of hematopoietic stem cells.