Development of method for neural activity manipulation using melanopsin

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Melanopsin is a light-activated membrane protein which is expressed in the part of ganglion cell in the retina. Melanopsin is activated by the blue light around 470 nm. Melanopsin send signal to intracellular via Gq protein. Melanopsin has higher light sensitivity compare with Channelrhodopsin. And the effect is lasted for long time. In this study, we tried to control specific type of neurons for long time by expressing melanopsin. We succeeded with establishing control method of neural activity by using weaker light.