Reconstitution of three-dimensional structures from the embryonickidney cells

胚胎肾脏含有肾单位祖细胞，它们与输尿管芽相互作用，分化成多个肾单位的谱系。随着诱导多能细胞的建立，许多研究人员致力于诱导肾单位祖细胞的分化。然而，仅有二维祖细胞的诱导并不足以再生肾脏，因此我们试图从胚胎肾单位重建三维结构，这将为我们提供肾脏再生的线索

The embryonic kidney contains nephron progenitors, which interact with the ureteric budto differentiate into multiple lineages of the nephron. Upon establishment of the inducedpluripotent cells, many researchers aim at induction of nephron progenitors. However,induction of two-dimensional progenitors alone is not sufficient to regenerate the kidney.Therefore we tried to reconstitute the three-dimensional structures from the embryonicnephron progenitors, which will give us a hint toward the kidney regeneration