Integration of cell sorting with metagenomic diagnosis system

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We have developed a metagenomic diagnosis system to diagnose infectious diseases by applying metagenomic analysis. This system has enabled us to directly detect pathogenic bacteria, influenza viruses and noroviruses from clinical samples. From those analyses, it has been found that contaminants such as host genome, bacteria, and/ or fungi in clinical samples reduce the efficiency and sensitivity of metagenomic detection. In order to improve the detection efficiency of the system, we developed a basic protocol of the metagenomic diagnosis system using cell-sorting technology.