Establishment and medical application of human mesenchymal stem cells with spinal cord injury repair action

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In previous study, we have shown that the locomotor functions of the rats are improved after complete transection of the spinal cord, when FGF-2is directly injected into the spinal cord immediately after transection. A massive tissue composed of FGF-2-induced fibronectin-positive cells (FIFs) had appeared and filled large cystic cavities, into which numerous axons penetrated and through which they coursed. In this study, we have examined the possible existence of FIF-like cells in the primate tissues. We found that the transplantation of human dental pulp cells but not those of FIF-like cells derived from monkey spinal cord improved the locomotor functions of the rats after complete transection of the spinal cord.