Metabolome analysis of head and neck cancer to identify the clinical markers

本研究采用气相色谱-质谱法对HNSCC患者进行代谢组学分析。分析血清和组织样本。在HNSCC患者的血清中，与糖酵解途径相关的几种代谢物水平较高，而几种氨基酸水平较低。与血清相比，HNSCC肿瘤组织中与糖酵解途径相关的几种代谢物水平低于非肿瘤组织，而几种氨基酸水平较高。我们的研究结果表明，代谢物模式的变化有助于评估HNSCC的临床特征，并有望建立新的诊断工具。

In this study, metabolome analysis of the patients with HNSCC was performed using gas chromatography mass spectrometry. Serum and tissue samples were analyzed. In serum,levels of severalmetabolites related to the glycolytic pathway were revealed to be higher in the patients with HNSCC, and the levels of severalamino acids were lower. In contrast to the sera, the levels of severalmetabolites related to the glycolytic pathway were revealed to be lower in the tumor tissues of HNSCC than the non-tumor tissues, and the levels of severalamino acids were higher. Our results demonstrate that changes in the metabolite pattern are useful for assessing the clinical characteristics of HNSCC, and will hopefully lead to the establishment of novel diagnostic tools.