Metabolome analysis of head and neck cancer to identify the clinical markers

头颈癌的代谢组分析以确定临床标志物

• 批准号: 23659795
• 负责人: NIBU Ken-ichi
• 金额: $ 2.33万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659795/
• 关键词: 頭頸部癌; プロテオソーム; 腫瘍マーカー; 質量分析; メタボローム解析; バイオマーカー; 代謝産物

In this study, metabolome analysis of the patients with HNSCC was performed using gas chromatography mass spectrometry. Serum and tissue samples were analyzed. In serum,levels of severalmetabolites related to the glycolytic pathway were revealed to be higher in the patients with HNSCC, and the levels of severalamino acids were lower. In contrast to the sera, the levels of severalmetabolites related to the glycolytic pathway were revealed to be lower in the tumor tissues of HNSCC than the non-tumor tissues, and the levels of severalamino acids were higher. Our results demonstrate that changes in the metabolite pattern are useful for assessing the clinical characteristics of HNSCC, and will hopefully lead to the establishment of novel diagnostic tools.

本研究采用气相色谱-质谱法对HNSCC患者进行代谢组学分析。对血清和组织标本进行分析。HNSCC患者血清中与糖酵解途径有关的几种代谢物水平较高，而几种氨基酸水平较低。与血清相比，HNSCC肿瘤组织中与糖酵解途径有关的几种代谢物水平低于非肿瘤组织，而几种氨基酸水平高于非肿瘤组织。我们的结果表明，代谢产物模式的改变有助于评估HNSCC的临床特征，并有望导致新的诊断工具的建立。

项目成果

In vitro and in vivo inhibitory effect of three Cox-2 inhibitors and epithelial-to-mesenchymal transition in human bladder cancer cell lines.

• DOI: 10.1038/bjc.2011.262
• 发表时间: 2011-07-26
• 期刊: BRITISH JOURNAL OF CANCER
• 影响因子: 8.8
• 作者: Adhim, Z.;Matsuoka, T.;Bito, T.;Shigemura, K.;Lee, K-M;Kawabata, M.;Fujisawa, M.;Nibu, K.;Shirakawa, T.
• 通讯作者: Shirakawa, T.

E10A, an adenovirus-carrying endostatin gene, dramatically increased the tumor drug concentration of metronomic chemotherapy with low-dose cisplatin in a xenograft mouse model for head and neck squamous-cell carcinoma

• DOI: 10.1038/cgt.2011.79
• 发表时间: 2012-02-01
• 期刊: CANCER GENE THERAPY
• 影响因子: 6.4
• 作者: Adhim, Z.;Lin, X.;Shirakawa, T.
• 通讯作者: Shirakawa, T.

Salvage surgery for recurrent oropharyngeal cancer after chemoradiotherapy

• DOI: 10.1007/s10147-012-0449-x
• 发表时间: 2013-10-01
• 期刊: INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
• 影响因子: 3.3
• 作者: Kano, Satoshi;Homma, Akihiro;Fujii, Masato
• 通讯作者: Fujii, Masato

Phase II Feasibility Trial of Adjuvant Chemoradiotherapy with 3-weekly Cisplatin for Japanese Patients with Post-operative High-risk Squamous Cell Carcinoma of the Head and Neck

• DOI: 10.1093/jjco/hys128
• 发表时间: 2012-10-01
• 期刊: JAPANESE JOURNAL OF CLINICAL ONCOLOGY
• 影响因子: 2.4
• 作者: Kiyota, Naomi;Tahara, Makoto;Ohtsu, Atsushi
• 通讯作者: Ohtsu, Atsushi

Radiotherapy for stage I or II hypopharyngeal carcinoma.

• DOI: 10.1093/jrr/rrs044
• 发表时间: 2012-11-01
• 期刊: Journal of radiation research
• 影响因子: 2
• 作者: Nishimura H;Sasaki R;Yoshida K;Miyawaki D;Okamoto Y;Kiyota N;Saito M;Otsuki N;Nibu K
• 通讯作者: Nibu K