Molecular mechanism and inhibitor development of platelet-dependent tumor growth progression in hematogenous metastasis

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The purpose of this study is to clarify the signal transduction pathways in cancer cells activated by interaction with platelets and to develop inhibitors against these signaling pathways. I found that direct interaction of platelets and sarcoma cells contributes to tumor malignancy by enhancing both tumor growth and tumor drug resistance, and identified PI3K-Akt pathway as a key signal transduction pathway which causes platelet-mediated tumor malignancy. Furthermore, sarcoma cell-induced platelet aggregation is dependent on platelet-aggregation inducing factor Aggrus, suggesting that anti-Aggrus neutralizing antibodies would be useful as hematogenous metastasis inhibitors against some types of cancers