Application of biogenic stealthy gold/magnetic composite nanoparticle to MRI contrast agent

合成了具有体内可识别性、隐身性和结合靶向生物分子能力的磁性复合纳米粒子。采用共沉淀法合成了磁性氧化铁纳米粒子，并将其作为复合粒子的核。聚乙二醇或金结合在氧化铁表面。制备了用于癌症治疗的磁性La-Sr-Mn氧化物微粒。这些粒子在交流磁场中产生热量，粒子温度随时间迅速升高，达到恒定值。

Magnetic composite nanoparticles with in vivo dispersibility, stealthy and capacity to bind a targeting biomolecule have been synthesized. Magnetic iron oxide nanoparticles synthesized by co-precipitation method were utilized as a core of composite particle. Polyethylene glycol or gold was bound on the surface of iron oxide. Magnetic La-Sr-Mn oxide fine particles were synthesized for cancer treatment. These particles generated heat in the AC magnetic field, and particle temperature increased quickly with time, attaining constant values.