Application of biogenic stealthy gold/magnetic composite nanoparticle to MRI contrast agent

生物隐形金/磁性复合纳米粒子在MRI造影剂中的应用

• 批准号: 23710133
• 负责人: KINOSHITA Takuya
• 金额: $ 2.91万
• 依托单位: Osaka Prefecture University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23710133/
• 关键词: 磁性ナノ粒子; MRI造影剤; PEG; 噴霧熱分解法; ハイパーサーミア; ＭＲＩ造影剤; ＰＥＧ; 金; 液相PLD法

Magnetic composite nanoparticles with in vivo dispersibility, stealthy and capacity to bind a targeting biomolecule have been synthesized. Magnetic iron oxide nanoparticles synthesized by co-precipitation method were utilized as a core of composite particle. Polyethylene glycol or gold was bound on the surface of iron oxide. Magnetic La-Sr-Mn oxide fine particles were synthesized for cancer treatment. These particles generated heat in the AC magnetic field, and particle temperature increased quickly with time, attaining constant values.

合成了具有体内可识别性、隐身性和结合靶向生物分子能力的磁性复合纳米粒子。采用共沉淀法合成了磁性氧化铁纳米粒子，并将其作为复合粒子的核。聚乙二醇或金结合在氧化铁表面。制备了用于癌症治疗的磁性La-Sr-Mn氧化物微粒。这些粒子在交流磁场中产生热量，粒子温度随时间迅速升高，达到恒定值。

项目成果

Synthesis of La0.75Sr0.25MnO3 fine particles for magnetic hyperthermia by ultrasonic spray pyrolysis

超声喷雾热解法合成磁热疗用La0.75Sr0.25MnO3细颗粒

• 发表时间: 2014
• 期刊: Japanese Journal of Applied Physics
• 影响因子: 1.5
• 作者: Takuya Kinoshita;Takamitsu Furuyabu;Motoaki Adachi
• 通讯作者: Motoaki Adachi

Synthesis of cobalt nanoparticle and fabrication of magnetoresistance devices by ion-assisted aerosol generation method

离子辅助气溶胶发生法钴纳米颗粒的合成及磁阻器件的制备

• DOI: 10.1080/02786826.2011.588729
• 发表时间: 2011
• 期刊: Aerosol Science and Technology
• 影响因子: 5.2
• 作者: Hiroyuki Shirai;Takuya Kinoshita;Motoaki Adachi
• 通讯作者: Motoaki Adachi

Synthesis of magnetic fine particles by ultrasonic spray pyrolysis for self-controlled magnetic hyperthermia

自控磁热热超声喷雾热解合成磁性细颗粒

• 发表时间: 2012
• 作者: Takamitsu Furuyabu;Ayako Yasuda;Takuya Kinoshita;Motoaki Adachi
• 通讯作者: Motoaki Adachi

Generation of Nanoparticles and Its Applications, Nanodroplets

纳米颗粒的生成及其应用，纳米液滴

• 发表时间: 2013
• 作者: M.Nama;T.Kinoshita;M.Adcahi;M. Adachi and T. Kinoshita
• 通讯作者: M. Adachi and T. Kinoshita

超音波噴霧熱分解法による金酸化鉄複合ナノ粒子の合成

超声喷雾热解法合成金铁氧化物复合纳米粒子

• 发表时间: 2011
• 作者: 渡邊周二;谷俊之;木下卓也;足立元明
• 通讯作者: 足立元明