Role of N-acetyl-glucosamine Metabolism in the Regulation of Macrophage Function and Atherosclerosis

N-乙酰氨基葡萄糖代谢在巨噬细胞功能和动脉粥样硬化调节中的作用

• 批准号: 24591117
• 负责人: KITAMOTO Shiro
• 金额: $ 3.41万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24591117/
• 关键词: 動脈硬化; マクロファージ; シグナル伝達; 生体分子; 糖鎖; マイクロファージ

项目成果

Suppression of abdominal aortic aneurysm formation by inhibition of prolyl hydroxylase domain protein through attenuation of inflammation and extracellular matrix disruption.

• DOI: 10.1042/cs20130435
• 发表时间: 2014-05
• 期刊: Clinical science
• 影响因子: 6
• 作者: Aya Watanabe;T. Ichiki;Chikahiro Sankoda;Yusuke Takahara;Jiro Ikeda;Eriko Inoue;T. Tokunou;S. Kitamo

Chitinase Inhibitor, Allosamidin, Accelerates Atherosclerotic Lesions in Hyperlipidemic Mice by Influencing M1/M2 Polarization and Cholesterol Metabolism in Macrophages

几丁质酶抑制剂 Allosamidin 通过影响巨噬细胞中的 M1/M2 极化和胆固醇代谢来加速高脂血症小鼠的动脉粥样硬化病变

• 作者: Shiro Kitamoto;Kensuke Egashira;Toshihiro Ichiki;Xinbing Han;Shohei Sakuda;Kenji Sunagawa;William A Boisvert
• 通讯作者: William A Boisvert

Deletion of phd2 in myeloid lineage attenuates hypertensive cardiovascular remodeling.

• DOI: 10.1161/jaha.113.000178
• 发表时间: 2013-06-18
• 期刊: Journal of the American Heart Association
• 影响因子: 5.4
• 作者: Ikeda J;Ichiki T;Matsuura H;Inoue E;Kishimoto J;Watanabe A;Sankoda C;Kitamoto S;Tokunou T;Takeda K;Fong GH;Sunagawa K
• 通讯作者: Sunagawa K

Chitinase Inhibition Promotes Atherosclerosis in Hyperlipidemic Mice

• DOI: 10.1016/j.ajpath.2013.04.003
• 发表时间: 2013-07-01
• 期刊: AMERICAN JOURNAL OF PATHOLOGY
• 影响因子: 6
• 作者: Kitamoto, Shiro;Egashira, Kensuke;Boisvert, William A.
• 通讯作者: Boisvert, William A.