Development of novel thymus-directed strategy for central immune tolerance induction in hemophilia A

开发用于血友病 A 中枢免疫耐受诱导的新型胸腺导向策略

• 批准号: 24591430
• 负责人: MADOIWA Seiji
• 金额: $ 3.41万
• 依托单位: Jichi Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24591430/
• 关键词: 血友病; インヒビター; 免疫寛容; 人工多能性幹細胞; 遺伝子治療; 細胞移植療法; 胸腺上皮細胞; 細胞療法

项目成果

Regulation of plasminogen activator inhibitor-1 promotes immune tolerance to factor VIII in murine hemophilia A

纤溶酶原激活剂抑制剂-1的调节促进小鼠血友病A对因子VIII的免疫耐受

• 发表时间: 2013
• 作者: Madoiwa S;Ohmori T;Kashiwakura Y;Sakata A;Mimuro J;Sakata Y
• 通讯作者: Sakata Y

Lack of association between serum paraoxonase-1 activity and residual platelet aggregation during dual anti-platelet therapy

双抗血小板治疗期间血清对氧磷酶-1 活性与残留血小板聚集之间缺乏关联

• DOI: 10.1016/j.thromres.2011.10.033
• 发表时间: 2012
• 期刊: Thromb Res
• 影响因子: 7.5
• 作者: Ohmori;T.;et al.
• 通讯作者: et al.

FTY720 Improves Functional Recovery after Spinal Cord Injury by Primarily Nonimmunomodulatory Mechanisms

• DOI: 10.1016/j.ajpath.2011.12.012
• 发表时间: 2012-04-01
• 期刊: AMERICAN JOURNAL OF PATHOLOGY
• 影响因子: 6
• 作者: Norimatsu, Yusuke;Ohmori, Tsukasa;Sakata, Yoichi
• 通讯作者: Sakata, Yoichi

Immune response against serial infusion of factor VIII antigen through an implantable venous-access device system in haemophilia A mice

• DOI: 10.1111/j.1365-2516.2011.02686.x
• 发表时间: 2012-05-01
• 期刊: HAEMOPHILIA
• 影响因子: 3.9
• 作者: Madoiwa, S.;Kobayashi, E.;Sakata, Y.
• 通讯作者: Sakata, Y.

Combination of thrombin-antithrombin complex, plasminogen activator inhibitor-1, and protein C activity for early identification of severe coagulopathy in initial phase of sepsis: a prospective observational study.

凝血酶 - 抗凝结蛋白复合物，纤溶酶原激活剂-1和蛋白C活性的结合，可在败血症的初始阶段早期鉴定出严重的凝血病：一项前瞻性观察性研究。

• DOI: 10.1186/cc13190
• 发表时间: 2014-01-13
• 期刊: Critical care (London, England)
• 作者: Koyama K;Madoiwa S;Nunomiya S;Koinuma T;Wada M;Sakata A;Ohmori T;Mimuro J;Sakata Y
• 通讯作者: Sakata Y