The new strategy of treatment of Kawasaki disease on the basis of gene expression in Kawasaki disease-like vasculitis mouse model

基于川崎病样血管炎小鼠模型基因表达的川崎病治疗新策略

• 批准号: 24791069
• 负责人: NAGATA Hazumu
• 金额: $ 2.75万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24791069/
• 关键词: 川崎病マウスモデル; サイトカイン; ケモカイン; 心エコー; 川崎病; 血管炎; 国際情報交換

Our previous research demonstrated that the gene associated with cytokine or chemokine was overexpressed in mouse model of Kawasaki disease-like vasculitis. In the present research, the administration of anti IL-6 antibody and anti CCL2 antibody could not suppress the inflammation. These results suggested that several cytokine and chemokine were related to the occurrence of vasculitis. The cardiac function of mouse model decreased gradually. There was no relation between the degree of inflammation of vasculitis and the level of echogenicity of coronary artery. We should increase the number of case and modify the methods.

我们前期的研究表明，与细胞因子或趋化因子相关的基因在川崎样血管炎小鼠模型中存在过表达。在本研究中，抗IL-6抗体和抗CCL 2抗体的给药不能抑制炎症。提示多种细胞因子和趋化因子与血管炎的发生有关。模型小鼠心功能逐渐下降。血管炎的炎症程度与冠状动脉回声水平无关。我们应该增加病例数并修改方法。

项目成果

Thrombocytosis in asplenia syndrome with congenital heart disease: A previously unrecognized risk factor for thromboembolism

• DOI: 10.1016/j.ijcard.2012.06.009
• 发表时间: 2013-09-01
• 期刊: INTERNATIONAL JOURNAL OF CARDIOLOGY
• 影响因子: 3.5
• 作者: Yamamura, Kenichiro;Joo, Kunitaka;Hara, Toshiro
• 通讯作者: Hara, Toshiro

Balloon-occluded retrograde transvenous obliteration for congenital portosystemic venous shunt: Report of two cases

• DOI: 10.1111/j.1442-200x.2011.03459.x
• 发表时间: 2012-06-01
• 期刊: PEDIATRICS INTERNATIONAL
• 影响因子: 1.4
• 作者: Nagata, Hazumu;Yamamura, Kenichiro;Hara, Toshiro
• 通讯作者: Hara, Toshiro

Left venricular efficiency after ligation of patent ductus arteriosus for premature infants

早产儿动脉导管未闭结扎术后左心室效率

• 发表时间: 2013
• 期刊: J Thorac Cardiovasc Surg
• 作者: Nagata H;Ihara K;Yamamura K;Tanoue Y;Shiokawa Y;Tominaga R;Hara T
• 通讯作者: Hara T

Systemic vascular phenotypes of Loeys-Dietz syndrome in a child carrying a de novo R381P mutation in TGFBR2: a case report.

• DOI: 10.1186/1756-0500-6-456
• 发表时间: 2013-11-12
• 期刊: BMC research notes
• 影响因子: 1.8
• 作者: Uike K;Matsushita Y;Sakai Y;Togao O;Nagao M;Ishizaki Y;Nagata H;Yamamura K;Torisu H;Hara T
• 通讯作者: Hara T

Early progression of atherosclerosis in children with chronic infantile neurological cutaneous and articular syndrome

慢性婴儿神经皮肤关节综合征儿童动脉粥样硬化的早期进展

• DOI: 10.1093/rheumatology/keu180
• 发表时间: 2014
• 期刊: Rheumatology
• 影响因子: 5.5
• 作者: Yamamura K;Takada H;Uike K;Nakashima Y;Hirata Y;Nagata H;Takimoto T;Ishimura M;Morihana E;Ohga S;Hara T
• 通讯作者: Hara T