Pathological analysis of chronic active EBV-infection rabbit model with hemophagocytosis
Pathological analysis of chronic active EBV-infection rabbit model with hemophagocytosis
批准号:
23590463
负责人:
HAYASHI Kazuhiko
金额:
$3.24万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
中文摘要
1)EBER-1ISH显示EBV阳性和阴性兔在接种EBV后终生观察;2)P3HR-1 EBNA-2缺失的EBV感染兔的效果低于B85-8的EBV原型。然而,这是唯一一个体内系统研究EBNA-2基因的功能。3)在兔EB病毒感染模型中,EB病毒主要包膜糖蛋白-350/220的合成肽不能预防感染。
英文摘要
1) EBER-1 ISH revealed EBV-positive and -negative rabbits lifelong observation after EBV-inoculation.2) EBNA-2-deleted EBV from P3HR-1 can infect rabbits with lower efficacy than prototype EBV from B85-8. However, this is the only one in vivo system to study the function of EBNA-2 gene.3) Synthetic peptides of Epstein-Barr Virus-major envelope glycoprotein-350/220 do not prevent infection in a rabbit Epstein-Barr Virus infection model.
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EBウイルス感染B細胞株の再活性化後期におけるEBERとgp350/ 220の局在 :72A1抗体を用いたP3HR-1細胞株の蛍光染色
EB 病毒感染的 B 细胞系晚期再激活过程中 EBER 和 gp350/220 的定位:使用 72A1 抗体对 P3HR-1 细胞系进行荧光染色
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[長田佳子, 檜垣克美, 中山祐二, 金井亨輔, 桐谷 唯, 佐野仁志, 加藤 郁, 木村 宏, 西蓮寺 剛, 林 一彦]
通讯作者:
林 一彦
EBウイルスと甲状腺疾患成人病と生活習慣病
EB病毒与甲状腺疾病 成人疾病和生活方式相关疾病
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Hirokazu Inoue, Yukihiro Tambe, Ken-ichi Mukaisho, Hiroyuki Sugihara, Takahiro Isono, Gen Kondoh, Chul Jang Kim, 長田佳子,林一彦]
通讯作者:
長田佳子,林一彦
In Vitro EBV infection Model of Rabbit Lymphocytes from Peripheral Blood or Spleen
兔外周血或脾脏淋巴细胞体外EBV感染模型
DOI:
--
发表时间:
2011
期刊:
Intervirology
影响因子:
4.6
作者:
[Kyosuke Kanai, Kaoru Kato, Hitoshi, Sano, Keiko Nagata, Keisuke Okuno, Satoshi Kuwamoto, Hiromi Higaki, Hirotsugu Sugihara, Masako Kato, Ichiro Murakami, Kazuhiko Hayashi]
通讯作者:
Kazuhiko Hayashi
In Vitro EBV infection Model of Rabbit Lymphocytes from Peripheral Blood or Spleen.
兔外周血或脾脏淋巴细胞的体外 EBV 感染模型。
DOI:
--
发表时间:
2011
期刊:
Intervirology
影响因子:
4.6
作者:
[Kyosuke Kanai1,4, Kaoru Kato1,2, Hitoshi Sano1,3, Keiko Nagata1, Keisuke Okuno1,3,Satoshi Kuwamoto1, Hiromi Higaki1, Hirotsugu Sugihara1, Masako Kato1, Ichiro Murakami1, Kazuhiko Hayashi1]
通讯作者:
Kazuhiko Hayashi1
バセドウ病患者の末梢血には、表面グロブリンとしてTSHレセプター抗体を持ち、EBウイルスに感染したBリンパ球が存在する
格雷夫斯病患者的外周血中存在感染EB病毒的B淋巴细胞,其表面球蛋白为TSH受体抗体。
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[長田佳子, 檜垣克美, 中山祐二, 宮内裕美, 桐谷唯, 越智万梨華, 金井亨輔, 難波栄二, 木村宏, 林一彦]
通讯作者:
林一彦
共 13 条
Establishment of MCPyV-infection experimental system and the therapy base on the carcinogenesis of MCPyV-positive Merkel cell carcinoma
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批准号:17K08720
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Development of methods for quality evaluation of actual concrete structures by surface water absorption test
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Development of novel biomaterial using poly(P) and bFGF onto porous hydroxyl apatite
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Development of New Implant Augmentation Drug Delivery System Using a rh-BMP-2-Gelatin Hydrogel Complex
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资助金额:$2.5万
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Research of the characteristics of disseminated gastric cancer cells and the factors of sensitivity and tolerance to chemotherapeutic agents.
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Influencing factors affecting steel corrosion of concrete members subjected to fatigue loading
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批准号:21760351
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Synthesis and Reaction of Strained Azabicyclic Compounds
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依托单位:
The first animal model for "Hit and Run" theory of oncogenesis by EBV related virus
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财政年份:2004
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依托单位:
Pathological analyses and therapeutic trials of animal model of EB virus-related fatal hemophagocytic syndrome
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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Analysis of speciation process in Liliaceae sensu lato
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依托单位:
ANIMAL MODEL FOR HUMAN EB VIRUS-RELATED TUMOR: PATHOGENESIS OF RABBIT LYMPHOMA INDUCED BY SIMIAN EBV-RELATED VIRUS
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T cell clonality of TIL (tumor-infiltrating lymphocytes) and PBL in vivo, and analysis of tumor-specific T cell clonotype
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负责人:HAYASHI Kazuhiko
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依托单位:
海外基金