Do epigenetics influences the form of a mandibular beyond the generation.

用软性食物喂养的大鼠与用硬性食物喂养的大鼠相比，其颅骨和下颌的形状发生了变化。在这一次，我们评估了先进的3DCT和正畸头部测量分析下颌形状的分析方法。因此，我们可以检测到饲喂粉末状饲料和饲喂固定硬质饲料的小鼠下颌骨形态的精细变化。此外，我们分析了这两组小鼠咬肌中的基因表达。两组间部分基因表达发生显著变化。进一步，我发现了MYH基因表达的反应，它在肌肉的一个特性中起着决定作用。这些结果表明，饲料硬度可能通过咬肌特性的改变而影响下颌骨的形态。

A rat fed with soft diet changes its cranial and mandibular form compared to a rat fed with hard diet. In this time, we assess the analysing method for the form of mandibular with advancing 3DCT and orthodontics cephalometric analysis. As a result, we could detect refined change of mandibular form in mice between grown with powdery feed and with fixed hard feed.Additionally, we analysed gene expression in masseter muscles in these two group mice. Some gene expression were significantly changed between these two groups. Further more, I find outthe reaction of MYH genes expression which play a role in deciding a character of muscle.These finding showes that the hardness of feed may influence to the form of mandibular via the change of chalacter of masseter muscle.