Do epigenetics influences the form of a mandibular beyond the generation.

与用硬饲料喂养的大鼠相比，用软饲料喂养的大鼠改变了其颅骨和下颌骨的形状。本研究通过三维CT和X线头影测量分析，探讨下颌骨形态的分析方法。因此，我们可以检测到用粉末饲料和固定硬饲料生长的小鼠下颌骨形态的精细变化，并分析了这两组小鼠咬肌中的基因表达。部分基因表达在两组间有显著性差异。进一步研究了MYH基因表达的反应，MYH基因的表达对咬肌性状的决定作用，这些结果表明，饲料硬度可能通过咬肌性状的改变而影响下颌骨的形态。

A rat fed with soft diet changes its cranial and mandibular form compared to a rat fed with hard diet. In this time, we assess the analysing method for the form of mandibular with advancing 3DCT and orthodontics cephalometric analysis. As a result, we could detect refined change of mandibular form in mice between grown with powdery feed and with fixed hard feed.Additionally, we analysed gene expression in masseter muscles in these two group mice. Some gene expression were significantly changed between these two groups. Further more, I find outthe reaction of MYH genes expression which play a role in deciding a character of muscle.These finding showes that the hardness of feed may influence to the form of mandibular via the change of chalacter of masseter muscle.