Development of photosensitizer with urea-Establishment of periodontal treatment combined with Er:YAG laser.

尿素光敏剂的研制——Er:YAG激光联合牙周治疗的建立。

• 批准号: 24792329
• 负责人: MINEOKA Akane
• 金额: $ 1.91万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24792329/
• 关键词: レーザー; 歯周病; LPS; 光感受性物質; ＬＰＳ

In recent years, there has been growing interest in the use of dental lasers for treatment of periodontal diseases. The purpose of this study was to acquire an effective Er:YAG laser treatment with photosensitizer and evaluate the effects of antimicrobial photodynamic therapy(aPDT) with urea-containing reagent as photosensitizer for periodontal treatment.It was comfirmed that the concentration of urea the most effectively involved in tarter removement was 5% urea.With urea-containing reagent application, the number of P.gingivalis decreased with increasing Er:YAG laser irradiation time in vitro. Laser with photosensitizer reagent group had a higher LPS elimination efficiency with increasing energy density,there was no significant difference between laser group and laser with photosensitizer reagent group though.

近年来，人们对使用牙科激光治疗牙周病越来越感兴趣。本研究的目的是获得一种有效的Er：YAG激光联合光敏剂治疗牙周病的方法，并评价含尿素试剂作为光敏剂的抗菌光动力疗法（aPDT）在牙周病治疗中的效果，确定5%尿素浓度对牙垢清除效果最好，含尿素试剂在体外对牙龈卟啉单胞菌（P.gingivalis）的清除效果随Er：YAG激光照射时间的延长而降低。随着能量密度的增加，激光加光敏剂组对LPS的清除效率更高，但激光组与激光加光敏剂组之间无显著差异。