Development of photosensitizer with urea-Establishment of periodontal treatment combined with Er:YAG laser.

近年来，人们对使用牙科激光治疗牙周病越来越感兴趣。本研究的目的是获得一种有效的Er:YAG激光光敏剂治疗牙周，并评价含尿素试剂作为光敏剂的抗菌光动力疗法（aPDT）在牙周治疗中的效果。结果表明，尿素浓度为5%时，对酒渣脱除效果最佳。在含脲试剂的作用下，随着Er:YAG激光照射时间的延长，牙龈假单胞菌的数量减少。随着能量密度的增加，激光加光敏剂组对LPS的消除效率更高，但激光加光敏剂组与激光加光敏剂组之间差异不显著。

In recent years, there has been growing interest in the use of dental lasers for treatment of periodontal diseases. The purpose of this study was to acquire an effective Er:YAG laser treatment with photosensitizer and evaluate the effects of antimicrobial photodynamic therapy(aPDT) with urea-containing reagent as photosensitizer for periodontal treatment.It was comfirmed that the concentration of urea the most effectively involved in tarter removement was 5% urea.With urea-containing reagent application, the number of P.gingivalis decreased with increasing Er:YAG laser irradiation time in vitro. Laser with photosensitizer reagent group had a higher LPS elimination efficiency with increasing energy density,there was no significant difference between laser group and laser with photosensitizer reagent group though.