Study for synthesis of organic molecules based on chiral organometallic catalysts containing C,N-polydentate ligands

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In this study, we elucidated the development of new transition metal catalyst containing carbon-nitrogen based chiral polydentate ligands. As a result, we have successfully synthesized new polydentate ligands containing oxazoline and N-heterocyclic carbene fragments and their transition metal complexes having rhodium, iridium, cobalt and ruthenium. In those catalysts, we developed several types of asymmetric transformations, namely asymmetric conjugate reduction of a,b-unsaturated carbonyl compounds, direct asymmetric alkynylation of aldehydes. In addition, we also found that pincer type iridium complexes exhibited C-H activation reaction of benzene derivatives and they served as a catalyst on bolylation reaction of aromatic compounds. Furthermore, the iridium complex was successfully applied to C-H activation of unactivated alkanes, giving the corresponding alkyl complexes.