Effect of n-3 fatty acids supplementation on hepatic phospholipid metabolism in nonalcoholic steatohepatitis.

喂食蛋氨酸和胆碱（MCD）缺乏的饮食是非酒精性脂肪性肝炎（NASH）最常见的模型之一。 我们分析了n-3脂肪酸（FA）补充对MCD喂养小鼠肝脏磷脂和损伤的影响。 在NASH MCD模型中，n-3 FA改善了血浆转氨酶水平和肝脏甘油三酯蓄积。 补充n-3 FA也改变了肝脏磷脂FA的组成，不仅包括多不饱和脂肪酸，还包括饱和脂肪酸。

Feeding a diet deficient in both methionine and choline (MCD) is one of the most common models of nonalcoholic steatohepatitis (NASH). We analyzed the effects of n-3 fatty acids (FA) supplementation on the hepatic phospholipids and injury in MCD fed mice. n-3 FA improved plasma transaminase levels and hepatic triglyceride accumulation in the MCD model of NASH. n-3 FA supplementation also changed liver phospholipids FA composition, not only polyunsaturated fatty acid but also saturated fatty acid.