iHA-100 exhibited a high efficacy whether administered during the early phase or late phase of H5N1 infection
iHA-100 exhibited a high efficacy whether administered during the early phase or late phase of H5N1 infection
批准号:
15H04739
负责人:
KOHARA Michinori
金额:
$11.07万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2015
资助国家:
日本
项目状态:
已结题
起止时间:
2015-04-01 至 2018-03-31
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弱毒化ワクシニアウイルスDIs株を母体とした組換えH5亜型HAインフルエンザワクチンによる発症防御機序の解析
减毒痘苗病毒DIs株重组H5亚型HA流感疫苗的保护机制分析
DOI:
--
发表时间:
2017
期刊:
影响因子:
--
作者:
[安井文彦, 宗片圭佑, 本田智子, 伊藤靖, 迫田義博, 喜田宏, 阪口薫雄, 小笠原一誠, 小原道法]
通讯作者:
小原道法
Elucidation of mechanism undergoing elimination of HPAI H5N1 virus in mice vaccinated with recombinant H5 vaccine based on vaccinia virus vector
阐明接种基于痘苗病毒载体的重组 H5 疫苗的小鼠体内消除 HPAI H5N1 病毒的机制
DOI:
--
发表时间:
2017
期刊:
影响因子:
--
作者:
[Yasui F., Munekata K., Honda T., Itoh Y., Sakoda Y., Kida H., Sakaguchi N., Ogasawara K., Kohara M.]
通讯作者:
Kohara M.
DOI:
10.1074/jbc.ra118.003862
发表时间:
2018-11-30
期刊:
JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子:
4.8
作者:
[Okamoto, Masaaki, Fukushima, Yoshimi, Oshiumi, Hiroyuki]
通讯作者:
Oshiumi, Hiroyuki
Prevention effect of H5N1 HPAI and H1N1 pdm2009 influenza vaccine based on highly attenuated vaccinia virus vector in cynomolgus monkeys
基于高度减毒牛痘病毒载体的H5N1 HPAI和H1N1 pdm2009流感疫苗对食蟹猴的预防效果
DOI:
--
发表时间:
2016
期刊:
影响因子:
--
作者:
[Munekata K., Yasui F., Itoh Y., Ishii K., Sakoda Y., Kida H., Ogasawara K., Kohara M.]
通讯作者:
Kohara M.
Highly pathogenic avian influenza virus (H5N1) causes severe symptoms due to insufficient induction of humoral immune responses
高致病性禽流感病毒(H5N1)由于体液免疫反应诱导不足而导致严重症状
DOI:
--
发表时间:
2015
期刊:
影响因子:
--
作者:
[Ai Ikejiri, Fumihiko Yasui, Nobuo Sakaguchi, Kazumasa Ogasawara, Michinori Kohara]
通讯作者:
Michinori Kohara
共 24 条
Pathology of spontaneous breast tumor in tree shrews (Tupaia belangeri chinenesis)
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批准号:18K19277
-
项目类别:Grant-in-Aid for Challenging Research (Exploratory)
-
资助金额:$4.16万
-
财政年份:2018
-
负责人:KOHARA Michinori
-
依托单位:
Macrocycles to target influenza viral hemagglutinin as bifunctional potent broad-spectrum antiviral agent
-
批准号:15K15146
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.41万
-
财政年份:2015
-
负责人:KOHARA Michinori
-
依托单位:
Influenza viral hemagglutinin-targeted macrocyclic peptides as an antiviral agent
-
批准号:25670224
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.5万
-
财政年份:2013
-
负责人:KOHARA Michinori
-
依托单位:
Tissue macrophages are responsible for inflammatory liver disease in the hepatitis C virus transgenic mice
-
批准号:24390117
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.98万
-
财政年份:2012
-
负责人:KOHARA Michinori
-
依托单位:
Influenza viral hemagglutinin-targeted macrocycles as an antiviral agent
-
批准号:23659238
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.41万
-
财政年份:2011
-
负责人:KOHARA Michinori
-
依托单位:
The specific SM molecular species that these endogenous SM species interacted with HCV nonstructural 5B polymerase to enhance viral replication
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批准号:21390145
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$11.81万
-
财政年份:2009
-
负责人:KOHARA Michinori
-
依托单位:
Persistent infection of Hepatitis C virus to get over the acquired immunity system
-
批准号:19041077
-
项目类别:Grant-in-Aid for Scientific Research on Priority Areas
-
资助金额:$10.5万
-
财政年份:2007
-
负责人:KOHARA Michinori
-
依托单位:
24-dehydrocholesterol reductase(DHCR24) inhibitor suppresses HCV replication
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批准号:18390146
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.77万
-
财政年份:2006
-
负责人:KOHARA Michinori
-
依托单位:
Determination of host factor for hepatitis C virus replication
-
批准号:16390139
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.54万
-
财政年份:2004
-
负责人:KOHARA Michinori
-
依托单位:
Impairment of the dimer formation of interferon regulatory factor-3 by hepatitis C virus core protein leads to evade interferon system
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批准号:14370106
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$8.9万
-
财政年份:2002
-
负责人:KOHARA Michinori
-
依托单位:
Characterization of HCV replication and pathogenesis in animal model
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批准号:11557025
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$8.64万
-
财政年份:1999
-
负责人:KOHARA Michinori
-
依托单位:
Analysis of persistent infection mechanism of RNA virus
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批准号:08457101
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$4.8万
-
财政年份:1996
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负责人:KOHARA Michinori
-
依托单位:
海外基金