Elucidation of the pathogenesis of stress-related psychiatric disorders based on the GAPDH cascade and development of treatment strategies
Elucidation of the pathogenesis of stress-related psychiatric disorders based on the GAPDH cascade and development of treatment strategies
批准号:
16H05029
负责人:
Nakajima Hidemitsu
金额:
$11.07万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2016
资助国家:
日本
项目状态:
已结题
起止时间:
2016-04-01 至 2020-03-31
中文摘要
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英文摘要
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Blockade of GAPDH nuclear translocation in the hippocampus contributes to anti-depressant-like action in stressed mice.
阻断海马区 GAPDH 核转位有助于应激小鼠的抗抑郁样作用。
DOI:
--
发表时间:
2017
期刊:
影响因子:
--
作者:
[Hidemitsu Nakajima, Sunao Nakamura, Akinori Kita, Chiho Senami, Mitsuru Kuwamura, Takatoshi Hikida, Yasu-Taka Azuma, and Tadayoshi Takeuchi]
通讯作者:
and Tadayoshi Takeuchi
Extracellular poly(ADP-ribose) is a neurotrophic signal that upregulates glial cell line-derived neurotrophic factor (GDNF) levels in vitro and in vivo.
细胞外聚(ADP-核糖)是一种神经营养信号,可在体外和体内上调神经胶质细胞系源性神经营养因子(GDNF)水平。
DOI:
10.1016/j.bbrc.2017.01.129
发表时间:
2017
期刊:
Biochem. Biophys. Res. Commun.
影响因子:
--
作者:
[Nakajima H, Itakura M, Sato K, Nakamura S, Azuma YT, Takeuchi T.]
通讯作者:
Takeuchi T.
ストレス性精神疾患モデルにおける海馬GAPDH核移行の病態生理学的意義
海马 GAPDH 核转位在应激性精神疾病模型中的病理生理意义
DOI:
--
发表时间:
2017
期刊:
影响因子:
--
作者:
[瀬浪千穂, 中嶋秀満, 東 泰孝, 竹内正吉]
通讯作者:
竹内正吉
DOI:
--
发表时间:
2016
期刊:
影响因子:
--
作者:
[Itakura M, Kubo T, Kaneshige A, Azuma YT, Hikida T, Takeuchi T, Nakajima H.]
通讯作者:
Nakajima H.
Oxidative stress-induced GAPDH nuclear translocation in the hippocampus causes depression behaviors by GR and BDNF downregulation in stressed mice.
氧化应激诱导的海马 GAPDH 核易位通过应激小鼠 GR 和 BDNF 下调导致抑郁行为。
DOI:
--
发表时间:
2019
期刊:
影响因子:
--
作者:
[Shoji M, Kita A, Uedo N, Ozaki Y, Azuma YT, Takeuchi T, and Nakajima H*]
通讯作者:
and Nakajima H*
共 16 条
Development of a new model of cat GAPDH knock-in Alzheimer's disease mice by the latest genome editing method
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批准号:17K19330
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项目类别:Grant-in-Aid for Challenging Research (Exploratory)
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资助金额:$4.16万
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财政年份:2017
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负责人:Nakajima Hidemitsu
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依托单位:
A novel therapeutic target for neurological disoders by inhibition of GAPDH aggregation
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批准号:25450428
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.41万
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财政年份:2013
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负责人:Nakajima Hidemitsu
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依托单位:
海外基金