ヒトｉＰＳ肝芽再構成系を用いた血液細胞との相互作用により肝細胞分化制御機構の解明

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In this study, we are going to understand how the dynamic interactions between hematopoietic and hepatic cells regulate liver development, and to generate the functional liver organoid that can be used for liver disease study and model. For this purpose, we try to establish an organoid to recapitulate hematopoietic-hepatic interactions during early liver organogenesis. Based on the developed hematopoietic-hepatic organoid, we have recapitulated the hepatic-hematopoietic symbiotic relationship. In the last year, we revealed the molecular mechanism of this symbiotic relationship. Monocyte is differentiated into M2 macrophage in the hepatic microenvironment, and the monocyte step-wisely promotes organoid development.