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Entwicklung, Konstruktion und Bau einer auf maximalen Ionentransfer optimierten AP-Ionisationsquelle zur massenspektrometrischen Analyse

开发、设计和构建 AP 电离源，针对质谱分析的最大离子传输进行优化

基本信息

批准号：
63383513
负责人：
Professor Dr. Thorsten Benter
金额：
--
依托单位：
Institut für Strahlantriebe und Turboarbeitsmaschinen (IST)
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2008
资助国家：
德国
起止时间：
2007-12-31 至 2012-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/63383513?language=en
关键词：
Entwicklung Konstruktion und Bau einer

项目摘要

The present proposal describes follow-up work as a continuation of the very successful joint effort of the three research groups Analytical, Physical and Theoretical Chemistry of the University Wuppertal, and the Institute of Jet Propulsion and Turbomachinery of the RWTH Aachen University. The work performed over the past three years, funded by the DFG, resulted in a number of major achievements with regard to a more fundamental understanding and deterministic development of atmospheric pressure ionization (API) sources. A pivotal role played high-quality computational fluid dynamics simulations, which were successfully used as input parameters for ion trajectory calculations. A couple of new generation API sources already operational are used in e.g. the analysis of polycyclic aromatic hydrocarbons. The main goal of the present proposal is a rigorous continuation, application, and extrapolation of the data and knowledge base assembled in the preceding three years. The present joint research efforts will focus on the development and analytical application of laminar low-flow and actively controlled high-flow API sources. These two novel designs were identified as the most powerful API source types. Preliminary sources at the initial design stage have already proven to be clearly superior to commercially available conventional API sources with regard to sensitivity, stability, and temporal resolution.

本提案介绍了后续工作，作为伍珀塔尔大学分析、物理和理论化学三个研究小组以及亚琛工业大学喷气推进和涡轮机械研究所非常成功的联合努力的延续。在过去三年中，由DFG资助的工作取得了一些重大成就，这些成就涉及对大气压电离（API）源的更基本的理解和确定性发展。高质量的计算流体动力学模拟发挥了关键作用，这些模拟成功地用作离子轨迹计算的输入参数。一些新一代的API源已经投入使用，例如用于多环芳烃的分析。本提案的主要目标是严格延续、应用和外推前三年收集的数据和知识库。目前的联合研究工作将侧重于层流低流量和主动控制高流量API源的开发和分析应用。这两种新颖的设计被认为是最强大的API源类型。初步设计阶段的初步源已被证明在灵敏度、稳定性和时间分辨率方面明显上级商业上可获得的常规API源。