Emerging viruses in West and South Africa: Molecular identification and characterization of rodent- and shrew-borne hantaviruses and assessment of their public health potential

西非和南非的新出现病毒：啮齿动物和鼩鼱传播的汉坦病毒的分子鉴定和特征分析及其公共卫生潜力评估

• 批准号: 69220050
• 负责人: Professor Dr. Detlev H. Krüger
• 金额: --
• 依托单位: Head Basic Vaccine Research
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2012-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/69220050?language=en
• 关键词: Emerging; viruses; West; South; Africa

Hantaviruses, members of the family Bunyaviridae, are emerging viruses causing two life-threatening human zoonoses; hemorrhagic fever with renal syndrome and hantavirus cardiopulmonary syndrome. The viruses are transmitted from animal reservoirs to humans. Based on our recent findings of hantaviruses in rodent as well as shrew reservoirs in Africa and their substantial implications in human health, the joint project of German and African groups will evaluate the biodiversity of hantaviruses and their natural animal reservoirs in western and southern Africa, the biological properties of the newly discovered viruses and the clinical significance of the African hantaviruses. This effort will result in capacity building for the detection and characterization of hantaviruses and other emerging viruses in African laboratories and to the development of virus-diagnostic and public health expertise for the control of rodent-borne zoonotic infections.

汉坦病毒是布尼亚病毒科的成员，是引起肾综合征出血热和汉坦病毒心肺综合征两种危及生命的人畜共患病的新兴病毒。病毒从动物宿主传播给人类。根据我们最近在非洲啮齿动物和鼩 鼱宿主中发现的汉坦病毒及其对人类健康的重大影响，德国和非洲小组的联合项目将评估西部和南部非洲汉坦病毒及其天然动物宿主的生物多样性、新发现病毒的生物学特性以及非洲汉坦病毒的临床意义。这一努力将导致在非洲实验室进行汉他病毒和其他新出现病毒的检测和定性能力建设，并发展病毒诊断和公共卫生专门知识，以控制啮齿动物传播的人畜共患传染病。