West African Emerging Infectious Disease Research Center (WA-EIDRC)

西非新发传染病研究中心 (WA-EIDRC)

• 批准号: 10440593
• 负责人: Kristian Graugaard Andersen
• 金额: $ 26.63万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-17 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10440593
• 关键词: Acute; Affect; Africa; African; Animals; Area; Awareness; Biological Assay; Chiroptera; Clinical; Clinical Management; Clustered Regularly Interspaced Short Palindromic Repeats; Collaborations; Communicable Diseases; Communication; Communities; Country; Decentralization; Detection; Development; Diagnostic; Diagnostic tests; Disease Outbreaks; Ebola; Educational workshop; Emerging Communicable Diseases; Ensure; Epidemic; Epidemiologist; Evolution; Foundations; Frequencies; Funding; Future; Genomics; Goals; Health; Human; Immune response; Infection; Infectious Diseases Research; Infrastructure; Knowledge; Lassa virus; Liberia; Metagenomics; Methods; Molecular Epidemiology; National Institute of Allergy and Infectious Disease; Natural History; Nigeria; Outcome; Pathogenesis; Patients; Plant Roots; Prevalence; Prevention strategy; Protocols documentation; Public Health; RNA; RNA Viruses; Rapid diagnostics; Reagent; Research; Research Personnel; Risk; Risk Factors; Rodent; Security; Senegal; Sierra Leone; Standardization; Surveys; System; Technology Transfer; Testing; Training; United States; United States National Institutes of Health; Viral Hemorrhagic Fevers; Virus; Virus Diseases; Work; World Bank; ZIKA; base; cohort; computerized tools; data sharing; diagnostic assay; diagnostic technologies; emerging pathogen; experience; flexibility; genome sequencing; improved; metagenomic sequencing; microbial; new technology; novel; pandemic disease; pandemic preparedness; pathogen; pathogenic virus; prevent; priority pathogen; public health emergency; public health intervention; response; surveillance study; technology development; tool; transmission process; viral transmission

Ensuring a world safe from microbial threats is a pressing challenge, as outbreaks exact tolls on human health, disrupt regional security, and have the potential to rapidly escalate into global crises. In recent years, severe outbreaks of Ebola, Lassa, Zika, and other emerging viruses have illustrated how vulnerable the world is to threats from RNA viral pathogens. These public health emergencies have exposed the urgent need for improved infrastructure, scientific knowledge, and diagnostic tools in areas of the world most at risk, and underscore the need for proactive pathogen surveillance, detection, and discovery. West Africa has a disproportionate vulnerability to outbreaks, but we lack awareness of acute threats, their natural history, and effective strategies for prevention. Rooted research between local and global partners, combined with novel assays and strategies for pandemic preparedness is required to answer these questions. We will build the capacity to rapidly respond to future outbreaks by establishing the West African Emerging Infectious Disease Research Center. This center will expand on years of successful cross-disciplinary research and capacity building, bringing together leading researchers from the United States, Liberia, Nigeria, Senegal, and Sierra Leone. We will: (1) perform comprehensive surveys of acute RNA viral disease and determine critical threats circulating in hosts and reservoirs; (2) identify risk factors of virus transmission and evolution; (3) dissect pathogenesis and natural history of severe RNA viral diseases; and (4) determine diagnostic criteria for infection outcome to guide public health interventions. Our work will significantly expand research capacity in West Africa via technology development of novel solutions for surveillance, diagnostics, and pathogen discovery. By establishing our center with a focus on priority pathogen research, technology transfer, training, and capacity building, we will develop flexible strategies for detecting, mitigating, and preventing the emergence of future infectious disease outbreaks.

确保世界不受微生物威胁是一项紧迫的挑战，因为疫情对人类造成了严重影响