West African Emerging Infectious Disease Research Center (WA-EIDRC)

西非新发传染病研究中心 (WA-EIDRC)

• 批准号: 10440593
• 负责人: Kristian Graugaard Andersen
• 金额: $ 26.63万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-17 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10440593
• 关键词: Acute; Affect; Africa; African; Animals; Area; Awareness; Biological Assay; Chiroptera; Clinical; Clinical Management; Clustered Regularly Interspaced Short Palindromic Repeats; Collaborations; Communicable Diseases; Communication; Communities; Country; Decentralization; Detection; Development; Diagnostic; Diagnostic tests; Disease Outbreaks; Ebola; Educational workshop; Emerging Communicable Diseases; Ensure; Epidemic; Epidemiologist; Evolution; Foundations; Frequencies; Funding; Future; Genomics; Goals; Health; Human; Immune response; Infection; Infectious Diseases Research; Infrastructure; Knowledge; Lassa virus; Liberia; Metagenomics; Methods; Molecular Epidemiology; National Institute of Allergy and Infectious Disease; Natural History; Nigeria; Outcome; Pathogenesis; Patients; Plant Roots; Prevalence; Prevention strategy; Protocols documentation; Public Health; RNA; RNA Viruses; Rapid diagnostics; Reagent; Research; Research Personnel; Risk; Risk Factors; Rodent; Security; Senegal; Sierra Leone; Standardization; Surveys; System; Technology Transfer; Testing; Training; United States; United States National Institutes of Health; Viral Hemorrhagic Fevers; Virus; Virus Diseases; Work; World Bank; ZIKA; base; cohort; computerized tools; data sharing; diagnostic assay; diagnostic technologies; emerging pathogen; experience; flexibility; genome sequencing; improved; metagenomic sequencing; microbial; new technology; novel; pandemic disease; pandemic preparedness; pathogen; pathogenic virus; prevent; priority pathogen; public health emergency; public health intervention; response; surveillance study; technology development; tool; transmission process; viral transmission

Ensuring a world safe from microbial threats is a pressing challenge, as outbreaks exact tolls on human health, disrupt regional security, and have the potential to rapidly escalate into global crises. In recent years, severe outbreaks of Ebola, Lassa, Zika, and other emerging viruses have illustrated how vulnerable the world is to threats from RNA viral pathogens. These public health emergencies have exposed the urgent need for improved infrastructure, scientific knowledge, and diagnostic tools in areas of the world most at risk, and underscore the need for proactive pathogen surveillance, detection, and discovery. West Africa has a disproportionate vulnerability to outbreaks, but we lack awareness of acute threats, their natural history, and effective strategies for prevention. Rooted research between local and global partners, combined with novel assays and strategies for pandemic preparedness is required to answer these questions. We will build the capacity to rapidly respond to future outbreaks by establishing the West African Emerging Infectious Disease Research Center. This center will expand on years of successful cross-disciplinary research and capacity building, bringing together leading researchers from the United States, Liberia, Nigeria, Senegal, and Sierra Leone. We will: (1) perform comprehensive surveys of acute RNA viral disease and determine critical threats circulating in hosts and reservoirs; (2) identify risk factors of virus transmission and evolution; (3) dissect pathogenesis and natural history of severe RNA viral diseases; and (4) determine diagnostic criteria for infection outcome to guide public health interventions. Our work will significantly expand research capacity in West Africa via technology development of novel solutions for surveillance, diagnostics, and pathogen discovery. By establishing our center with a focus on priority pathogen research, technology transfer, training, and capacity building, we will develop flexible strategies for detecting, mitigating, and preventing the emergence of future infectious disease outbreaks.

确保世界安全不受微生物威胁是一项紧迫的挑战，因为疫情对人类造成了确切的影响 这会破坏健康，破坏区域安全，并有可能迅速升级为全球危机。在最近 多年来，埃博拉、拉萨、寨卡和其他新兴病毒的严重爆发表明， 世界面临着来自RNA病毒病原体的威胁。这些突发公共卫生事件暴露了 迫切需要改善世界各地的基础设施、科学知识和诊断工具 大多数处于危险之中，并强调需要积极主动地监测、检测和发现病原体。 西非对疫情的脆弱性极高，但我们缺乏对严重威胁的认识， 他们的自然历史和有效的预防战略。在本地和全球之间扎根的研究 需要合作伙伴结合新的大流行防备分析和战略来回答 这些问题。我们将建立快速应对未来疫情的能力，建立 西非新发传染病研究中心。这个中心将在多年成功的基础上扩大 跨学科研究和能力建设，汇聚了来自美国的领先研究人员 美国、利比里亚、尼日利亚、塞内加尔和塞拉利昂。我们会：(1)全面调查非典型肺炎 核糖核酸病毒病，并确定在宿主和宿主中传播的关键威胁；(2)确定风险因素 病毒的传播和进化；(3)对重症RNA病毒的发病机制和自然病程进行了剖析 (4)确定感染结果的诊断标准，以指导公共卫生干预。 我们的工作将通过开发新颖的技术来显著扩大西非的研究能力 用于监测、诊断和病原体发现的解决方案。通过建立我们的中心，专注于 优先病原菌研究、技术转让、培训和能力建设，我们将制定灵活的 检测、减轻和预防未来传染病暴发的战略。