West African Emerging Infectious Disease Research Center (WA-EIDRC)
West African Emerging Infectious Disease Research Center (WA-EIDRC)
批准号:
10440593
负责人:
Kristian Graugaard Andersen
金额:
$26.63万
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
已结题
起止时间:
2021-08-17 至 2023-04-30
关键词:
AcuteAffectAfricaAfricanAnimalsAreaAwarenessBiological AssayChiropteraClinicalClinical ManagementClustered Regularly Interspaced Short Palindromic RepeatsCollaborationsCommunicable DiseasesCommunicationCommunitiesCountryDecentralizationDetectionDevelopmentDiagnosticDiagnostic testsDisease OutbreaksEbolaEducational workshopEmerging Communicable DiseasesEnsureEpidemicEpidemiologistEvolutionFoundationsFrequenciesFundingFutureGenomicsGoalsHealthHumanImmune responseInfectionInfectious Diseases ResearchInfrastructureKnowledgeLassa virusLiberiaMetagenomicsMethodsMolecular EpidemiologyNational Institute of Allergy and Infectious DiseaseNatural HistoryNigeriaOutcomePathogenesisPatientsPlant RootsPrevalencePrevention strategyProtocols documentationPublic HealthRNARNA VirusesRapid diagnosticsReagentResearchResearch PersonnelRiskRisk FactorsRodentSecuritySenegalSierra LeoneStandardizationSurveysSystemTechnology TransferTestingTrainingUnited StatesUnited States National Institutes of HealthViral Hemorrhagic FeversVirusVirus DiseasesWorkWorld BankZIKAbasecohortcomputerized toolsdata sharingdiagnostic assaydiagnostic technologiesemerging pathogenexperienceflexibilitygenome sequencingimprovedmetagenomic sequencingmicrobialnew technologynovelpandemic diseasepandemic preparednesspathogenpathogenic viruspreventpriority pathogenpublic health emergencypublic health interventionresponsesurveillance studytechnology developmenttooltransmission processviral transmission
中文摘要
确保世界免受微生物威胁是一项紧迫的挑战,因为疫情对人类造成了严重影响。
健康,破坏地区安全,并有可能迅速升级为全球危机。近几
多年来,埃博拉、拉沙、寨卡和其他新兴病毒的严重爆发表明,
RNA病毒病原体的威胁。这些突发公共卫生事件暴露了
世界各地迫切需要改善基础设施、科学知识和诊断工具
最危险的,并强调需要主动病原体监测,检测和发现。
西非对疫情的脆弱性不成比例,但我们缺乏对严重威胁的认识,
它们的自然历史和有效的预防策略。在本地和全球之间进行深入研究
需要合作伙伴,结合新的检测方法和流行病防范战略,
这些问题。我们将建立快速应对未来疫情的能力,
西非新发传染病研究中心。该中心将在多年成功的基础上扩大
跨学科研究和能力建设,汇集了来自美国的领先研究人员
美国、利比里亚、尼日利亚、塞内加尔和塞拉利昂。我们将:(1)进行全面的调查,
RNA病毒疾病,并确定在宿主和宿主中传播的关键威胁;(2)确定风险因素
(3)剖析了重症RNA病毒的发病机理和自然史
疾病;(4)确定感染结果的诊断标准,以指导公共卫生干预。
我们的工作将通过新技术的开发,大大扩大西非的研究能力。
用于监测、诊断和病原体发现的解决方案。通过建立我们的中心,
优先病原体研究,技术转让,培训和能力建设,我们将制定灵活的
检测、缓解和预防未来传染病暴发的战略。
英文摘要
Ensuring a world safe from microbial threats is a pressing challenge, as outbreaks exact tolls on human
health, disrupt regional security, and have the potential to rapidly escalate into global crises. In recent
years, severe outbreaks of Ebola, Lassa, Zika, and other emerging viruses have illustrated how vulnerable
the world is to threats from RNA viral pathogens. These public health emergencies have exposed the
urgent need for improved infrastructure, scientific knowledge, and diagnostic tools in areas of the world
most at risk, and underscore the need for proactive pathogen surveillance, detection, and discovery.
West Africa has a disproportionate vulnerability to outbreaks, but we lack awareness of acute threats,
their natural history, and effective strategies for prevention. Rooted research between local and global
partners, combined with novel assays and strategies for pandemic preparedness is required to answer
these questions. We will build the capacity to rapidly respond to future outbreaks by establishing the
West African Emerging Infectious Disease Research Center. This center will expand on years of successful
cross-disciplinary research and capacity building, bringing together leading researchers from the United
States, Liberia, Nigeria, Senegal, and Sierra Leone. We will: (1) perform comprehensive surveys of acute
RNA viral disease and determine critical threats circulating in hosts and reservoirs; (2) identify risk factors
of virus transmission and evolution; (3) dissect pathogenesis and natural history of severe RNA viral
diseases; and (4) determine diagnostic criteria for infection outcome to guide public health interventions.
Our work will significantly expand research capacity in West Africa via technology development of novel
solutions for surveillance, diagnostics, and pathogen discovery. By establishing our center with a focus on
priority pathogen research, technology transfer, training, and capacity building, we will develop flexible
strategies for detecting, mitigating, and preventing the emergence of future infectious disease outbreaks.
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West African Emerging Infectious Disease Research Center (WA-EIDRC)
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批准号:10653441
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项目类别:
-
资助金额:$184.89万
-
财政年份:2022
-
负责人:Kristian Graugaard Andersen
-
依托单位:
Consortium for Viral Systems Biology (CViSB)
-
批准号:10469781
-
项目类别:
-
资助金额:$59.71万
-
财政年份:2021
-
负责人:Kristian Graugaard Andersen
-
依托单位:
Consortium for Viral Systems Biology Administrative Core
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批准号:10469782
-
项目类别:
-
资助金额:$59.71万
-
财政年份:2021
-
负责人:Kristian Graugaard Andersen
-
依托单位:
West African Emerging Infectious Disease Research Center (WA-EIDRC)
-
批准号:10631738
-
项目类别:
-
资助金额:$35.86万
-
财政年份:2020
-
负责人:Kristian Graugaard Andersen
-
依托单位:
West African Emerging Infectious Disease Research Center (WA-EIDRC)
-
批准号:10910587
-
项目类别:
-
资助金额:$23.6万
-
财政年份:2020
-
负责人:Kristian Graugaard Andersen
-
依托单位:
West African Emerging Infectious Disease Research Center (WA-EIDRC)
-
批准号:10394323
-
项目类别:
-
资助金额:$174.99万
-
财政年份:2020
-
负责人:Kristian Graugaard Andersen
-
依托单位:
West African Emerging Infectious Disease Research Center (WA-EIDRC)
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批准号:10842168
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项目类别:
-
资助金额:$80.18万
-
财政年份:2020
-
负责人:Kristian Graugaard Andersen
-
依托单位:
West African Emerging Infectious Disease Research Center (WA-EIDRC)
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批准号:10616665
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项目类别:
-
资助金额:$174.13万
-
财政年份:2020
-
负责人:Kristian Graugaard Andersen
-
依托单位:
Consortium for Viral Systems Biology Administrative Core
-
批准号:10579082
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项目类别:
-
资助金额:$7.5万
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财政年份:2018
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负责人:Kristian Graugaard Andersen
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依托单位:
Consortium for Viral Systems Biology (CViSB)
-
批准号:10248803
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项目类别:
-
资助金额:$25.0万
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财政年份:2018
-
负责人:Kristian Graugaard Andersen
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依托单位:
Systems biology of Ebola virus and Lassa virus determinants of infection outcome
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批准号:10310606
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项目类别:
-
资助金额:$11.52万
-
财政年份:2018
-
负责人:Kristian Graugaard Andersen
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依托单位:
Consortium for Viral Systems Biology Administrative Core
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批准号:10310601
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项目类别:
-
资助金额:$7.29万
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财政年份:2018
-
负责人:Kristian Graugaard Andersen
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依托单位:
Project 2
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批准号:10558424
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项目类别:
-
资助金额:$64.26万
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财政年份:2018
-
负责人:Kristian Graugaard Andersen
-
依托单位:
Consortium for Viral Systems Biology (CViSB)
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批准号:10374714
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项目类别:
-
资助金额:$255.0万
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财政年份:2018
-
负责人:Kristian Graugaard Andersen
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依托单位:
Consortium for Viral Systems Biology (CViSB)
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批准号:10579081
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项目类别:
-
资助金额:$45.0万
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财政年份:2018
-
负责人:Kristian Graugaard Andersen
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依托单位:
Administrative Core
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批准号:10558419
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项目类别:
-
资助金额:$31.68万
-
财政年份:2018
-
负责人:Kristian Graugaard Andersen
-
依托单位:
Consortium for Viral Systems Biology (CViSB)
-
批准号:10356250
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项目类别:
-
资助金额:$45.0万
-
财政年份:2018
-
负责人:Kristian Graugaard Andersen
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依托单位:
Systems biology of Ebola virus and Lassa virus determinants of infection outcome
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批准号:10374720
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项目类别:
-
资助金额:$42.5万
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财政年份:2018
-
负责人:Kristian Graugaard Andersen
-
依托单位:
Systems biology of Ebola virus and Lassa virus determinants of infection outcome
-
批准号:10579087
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项目类别:
-
资助金额:$7.5万
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财政年份:2018
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负责人:Kristian Graugaard Andersen
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依托单位:
Center for Viral Systems Biology (CViSB)
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批准号:10558418
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项目类别:
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资助金额:$265.04万
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财政年份:2018
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负责人:Kristian Graugaard Andersen
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依托单位:
海外基金