West African Emerging Infectious Disease Research Center (WA-EIDRC)

西非新发传染病研究中心 (WA-EIDRC)

• 批准号: 10440593
• 负责人: Kristian Graugaard Andersen
• 金额: $ 26.63万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-17 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10440593
• 关键词: Acute; Affect; Africa; African; Animals; Area; Awareness; Biological Assay; Chiroptera; Clinical; Clinical Management; Clustered Regularly Interspaced Short Palindromic Repeats; Collaborations; Communicable Diseases; Communication; Communities; Country; Decentralization; Detection; Development; Diagnostic; Diagnostic tests; Disease Outbreaks; Ebola; Educational workshop; Emerging Communicable Diseases; Ensure; Epidemic; Epidemiologist; Evolution; Foundations; Frequencies; Funding; Future; Genomics; Goals; Health; Human; Immune response; Infection; Infectious Diseases Research; Infrastructure; Knowledge; Lassa virus; Liberia; Metagenomics; Methods; Molecular Epidemiology; National Institute of Allergy and Infectious Disease; Natural History; Nigeria; Outcome; Pathogenesis; Patients; Plant Roots; Prevalence; Prevention strategy; Protocols documentation; Public Health; RNA; RNA Viruses; Rapid diagnostics; Reagent; Research; Research Personnel; Risk; Risk Factors; Rodent; Security; Senegal; Sierra Leone; Standardization; Surveys; System; Technology Transfer; Testing; Training; United States; United States National Institutes of Health; Viral Hemorrhagic Fevers; Virus; Virus Diseases; Work; World Bank; ZIKA; base; cohort; computerized tools; data sharing; diagnostic assay; diagnostic technologies; emerging pathogen; experience; flexibility; genome sequencing; improved; metagenomic sequencing; microbial; new technology; novel; pandemic disease; pandemic preparedness; pathogen; pathogenic virus; prevent; priority pathogen; public health emergency; public health intervention; response; surveillance study; technology development; tool; transmission process; viral transmission

Ensuring a world safe from microbial threats is a pressing challenge, as outbreaks exact tolls on human health, disrupt regional security, and have the potential to rapidly escalate into global crises. In recent years, severe outbreaks of Ebola, Lassa, Zika, and other emerging viruses have illustrated how vulnerable the world is to threats from RNA viral pathogens. These public health emergencies have exposed the urgent need for improved infrastructure, scientific knowledge, and diagnostic tools in areas of the world most at risk, and underscore the need for proactive pathogen surveillance, detection, and discovery. West Africa has a disproportionate vulnerability to outbreaks, but we lack awareness of acute threats, their natural history, and effective strategies for prevention. Rooted research between local and global partners, combined with novel assays and strategies for pandemic preparedness is required to answer these questions. We will build the capacity to rapidly respond to future outbreaks by establishing the West African Emerging Infectious Disease Research Center. This center will expand on years of successful cross-disciplinary research and capacity building, bringing together leading researchers from the United States, Liberia, Nigeria, Senegal, and Sierra Leone. We will: (1) perform comprehensive surveys of acute RNA viral disease and determine critical threats circulating in hosts and reservoirs; (2) identify risk factors of virus transmission and evolution; (3) dissect pathogenesis and natural history of severe RNA viral diseases; and (4) determine diagnostic criteria for infection outcome to guide public health interventions. Our work will significantly expand research capacity in West Africa via technology development of novel solutions for surveillance, diagnostics, and pathogen discovery. By establishing our center with a focus on priority pathogen research, technology transfer, training, and capacity building, we will develop flexible strategies for detecting, mitigating, and preventing the emergence of future infectious disease outbreaks.

确保世界免受微生物威胁是一项紧迫的挑战，因为疫情的爆发造成了人类的死亡 健康、扰乱地区安全，并有可能迅速升级为全球危机。近来 多年来，埃博拉、拉沙、寨卡和其他新出现的病毒的严重爆发表明了病毒的脆弱性 世界正面临来自RNA病毒病原体的威胁。这些突发公共卫生事件暴露了 世界各地迫切需要改善基础设施、科学知识和诊断工具 风险最大，并强调需要主动监测、检测和发现病原体。 西非非常容易遭受疫情爆发，但我们缺乏对严重威胁的认识， 它们的自然历史以及有效的预防策略。植根于本地和全球之间的研究 需要合作伙伴结合新的检测方法和大流行防范策略来回答 这些问题。我们将通过建立快速应对未来疫情爆发的能力来建立 西非新发传染病研究中心。该中心将在多年成功经验的基础上进行扩展 跨学科研究和能力建设，汇集了来自美国的领先研究人员 国、利比里亚、尼日利亚、塞内加尔和塞拉利昂。我们将：（1）对急性发作进行全面调查 RNA病毒病并确定在宿主和宿主中传播的关键威胁； (2)识别风险因素 病毒传播和进化； (3) 剖析重症RNA病毒的发病机制和自然史 疾病； (4) 确定感染结果的诊断标准以指导公共卫生干预措施。 我们的工作将通过新颖的技术开发显着扩大西非的研究能力 用于监测、诊断和病原体发现的解决方案。通过建立我们的中心，重点关注 优先病原体研究、技术转让、培训和能力建设，我们将开发灵活的 检测、减轻和预防未来传染病爆发的策略。