West African Emerging Infectious Disease Research Center (WA-EIDRC)

西非新发传染病研究中心 (WA-EIDRC)

• 批准号: 10910587
• 负责人: Kristian Graugaard Andersen
• 金额: $ 23.6万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-21 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10910587
• 关键词: Acceleration; Acute; Affect; Africa; African; Animals; Area; Awareness; Biological Assay; Chiroptera; Clinical; Clinical Management; Clustered Regularly Interspaced Short Palindromic Repeats; Collaborations; Communicable Diseases; Communication; Communities; Country; Decentralization; Detection; Development; Diagnostic; Diagnostic tests; Disease Outbreaks; Ebola; Educational workshop; Emerging Communicable Diseases; Ensure; Epidemic; Epidemiologist; Evolution; Foundations; Frequencies; Funding; Future; Genomics; Goals; Health; Human; Immune response; Infection; Infectious Diseases Research; Infrastructure; Knowledge; Lassa virus; Liberia; Metagenomics; Methods; Molecular Epidemiology; National Institute of Allergy and Infectious Disease; Natural History; Nigeria; Outcome; Pathogenesis; Patients; Persons; Prevalence; Prevention strategy; Protocols documentation; Public Health; RNA; RNA Viruses; Rapid diagnostics; Reaction; Reagent; Research; Research Personnel; Risk; Risk Factors; Rodent; Security; Senegal; Sierra Leone; Standardization; Surveys; System; Technology Transfer; Testing; Training; United States; United States National Institutes of Health; Viral Hemorrhagic Fevers; Virus; Virus Diseases; Work; World Bank; ZIKA; cohort; computerized tools; data sharing; diagnostic assay; diagnostic criteria; diagnostic technologies; diagnostic tool; emerging pathogen; experience; flexibility; future outbreak; future pandemic; genome sequencing; improved; metagenomic sequencing; microbial; new outbreak; new technology; novel; pandemic potential; pandemic preparedness; pathogen; pathogenic virus; prevent; priority pathogen; public health emergency; public health intervention; public health relevance; response; technology development; tool; transmission process; viral transmission

Abstract Ensuring a world safe from microbial threats is a pressing challenge, as outbreaks exact tolls on human health, disrupt regional security, and have the potential to rapidly escalate into global crises. In recent years, severe outbreaks of Ebola, Lassa, Zika, and other emerging viruses have illustrated how vulnerable the world is to threats from RNA viral pathogens. These public health emergencies have exposed the urgent need for improved infrastructure, scientific knowledge, and diagnostic tools in areas of the world most at risk, and underscore the need for proactive pathogen surveillance, detection, and discovery. West Africa has a disproportionate vulnerability to outbreaks, but we lack awareness of acute threats, their natural history, and effective strategies for prevention. Rooted research between local and global partners, combined with novel assays and strategies for pandemic preparedness is required to answer these questions. We will build the capacity to rapidly respond to future outbreaks by establishing the West African Research Network for Infectious Diseases. This network will expand on years of successful cross-disciplinary research and capacity building, bringing together leading researchers from the United States, Liberia, Nigeria, Senegal, and Sierra Leone. We will: (1) perform comprehensive surveys of acute RNA viral disease and determine critical threats circulating in hosts and reservoirs; (2) identify risk factors of virus transmission and evolution; (3) dissect pathogenesis and natural history of severe RNA viral diseases; and (4) determine diagnostic criteria for infection outcome to guide public health interventions. Our work will significantly expand research capacity in West Africa via technology development of novel solutions for surveillance, diagnostics, and pathogen discovery. By establishing our network with a focus on priority pathogen research, technology transfer, training, and capacity building, we will develop flexible strategies for detecting, mitigating, and preventing the emergence of future infectious disease outbreaks.

抽象的 确保世界免受微生物威胁是一项紧迫的挑战，因为疫情的爆发会严重影响人类健康，扰乱地区安全，并有可能迅速升级为全球危机。近年来，埃博拉、拉沙、寨卡和其他新兴病毒的严重爆发表明，世界是多么容易受到 RNA 病毒病原体的威胁。这些突发公共卫生事件暴露了世界上风险最高的地区迫切需要改善基础设施、科学知识和诊断工具，并强调主动监测、检测和发现病原体的必要性。西非非常容易爆发疫情，但我们缺乏对严重威胁、其自然历史和有效预防策略的认识。回答这些问题需要当地和全球合作伙伴之间的深入研究，结合新的检测方法和大流行防范策略。我们将通过建立西非传染病研究网络来建设快速应对未来疫情爆发的能力。该网络将在多年成功的跨学科研究和能力建设的基础上进行扩展，汇集来自美国、利比里亚、尼日利亚、塞内加尔和塞拉利昂的领先研究人员。我们将：（1）对急性RNA病毒病进行全面调查，确定在宿主和宿主中传播的关键威胁； （2）识别病毒传播和进化的危险因素； (3) 剖析严重RNA病毒性疾病的发病机制和自然史； (4) 确定感染结果的诊断标准以指导公共卫生干预措施。我们的工作将通过监测、诊断和病原体发现的新型解决方案的技术开发，显着扩大西非的研究能力。通过建立重点关注病原体研究、技术转让、培训和能力建设的网络，我们将制定灵活的战略来检测、减轻和预防未来传染病爆发的出现。

项目成果

Streamlined inactivation, amplification, and Cas13-based detection of SARS-CoV-2.

基于SARS-COV-2的基于SARS-COV-2的基于SARS-COV-2的基于简化的灭活，扩增和CAS13的检测。

• DOI: 10.1038/s41467-020-19097-x
• 发表时间: 2020-11-20
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Arizti-Sanz J;Freije CA;Stanton AC;Petros BA;Boehm CK;Siddiqui S;Shaw BM;Adams G;Kosoko-Thoroddsen TF;Kemball ME;Uwanibe JN;Ajogbasile FV;Eromon PE;Gross R;Wronka L;Caviness K;Hensley LE;Bergman NH;MacInnis BL;Happi CT;Lemieux JE;Sabeti PC;Myhrvold C
• 通讯作者: Myhrvold C

Space-Time Trends in Lassa Fever in Sierra Leone by ELISA Serostatus, 2012-2019.

• DOI: 10.3390/microorganisms9030586
• 发表时间: 2021-03-12
• 期刊: Microorganisms
• 影响因子: 4.5
• 作者: Shaffer JG;Schieffelin JS;Momoh M;Goba A;Kanneh L;Alhasan F;Gbakie M;Engel EJ;Bond NG;Hartnett JN;Nelson DKS;Bush DJ;Boisen ML;Heinrich ML;Rowland MM;Branco LM;Samuels RJ;Garry RF;Grant DS;The Viral Hemorrhagic Fever Consortium
• 通讯作者: The Viral Hemorrhagic Fever Consortium

Microbial metagenomic approach uncovers the first rabbit haemorrhagic disease virus genome in Sub-Saharan Africa.

• DOI: 10.1038/s41598-021-91961-2
• 发表时间: 2021-07-01
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Happi AN;Ogunsanya OA;Oguzie JU;Oluniyi PE;Olono AS;Heeney JL;Happi CT
• 通讯作者: Happi CT

VGEA: an RNA viral assembly toolkit.

• DOI: 10.7717/peerj.12129
• 发表时间: 2021
• 期刊: PeerJ
• 影响因子: 2.7
• 作者: Oluniyi PE;Ajogbasile F;Oguzie J;Uwanibe J;Kayode A;Happi A;Ugwu A;Olumade T;Ogunsanya O;Eromon PE;Folarin O;Frost SDW;Heeney J;Happi CT
• 通讯作者: Happi CT

Whole genome sequencing unravels cryptic circulation of divergent dengue virus lineages in the rainforest region of Nigeria.

• DOI: 10.1080/22221751.2024.2307511
• 发表时间: 2024-12
• 期刊: Emerging microbes & infections
• 影响因子: 13.2