West African Emerging Infectious Disease Research Center (WA-EIDRC)

西非新发传染病研究中心 (WA-EIDRC)

基本信息

批准号：
10910587
负责人：
Kristian Graugaard Andersen
金额：
$ 23.6万
依托单位：
SCRIPPS RESEARCH INSTITUTE, THE
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-21 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10910587
关键词：
Acceleration Acute Affect Africa African Animals Area Awareness Biological Assay Chiroptera Clinical Clinical Management Clustered Regularly Interspaced Short Palindromic Repeats Collaborations Communicable Diseases Communication Communities Country Decentralization Detection Development Diagnostic Diagnostic tests Disease Outbreaks Ebola Educational workshop Emerging Communicable Diseases Ensure Epidemic Epidemiologist Evolution Foundations Frequencies Funding Future Genomics Goals Health Human Immune response Infection Infectious Diseases Research Infrastructure Knowledge Lassa virus Liberia Metagenomics Methods Molecular Epidemiology National Institute of Allergy and Infectious Disease Natural History Nigeria Outcome Pathogenesis Patients Persons Prevalence Prevention strategy Protocols documentation Public Health RNA RNA Viruses Rapid diagnostics Reaction Reagent Research Research Personnel Risk Risk Factors Rodent Security Senegal Sierra Leone Standardization Surveys System Technology Transfer Testing Training United States United States National Institutes of Health Viral Hemorrhagic Fevers Virus Virus Diseases Work World Bank ZIKA cohort computerized tools data sharing diagnostic assay diagnostic criteria diagnostic technologies diagnostic tool emerging pathogen experience flexibility future outbreak future pandemic genome sequencing improved metagenomic sequencing microbial new outbreak new technology novel pandemic potential pandemic preparedness pathogen pathogenic virus prevent priority pathogen public health emergency public health intervention public health relevance response technology development tool transmission process viral transmission

项目摘要

Abstract Ensuring a world safe from microbial threats is a pressing challenge, as outbreaks exact tolls on human health, disrupt regional security, and have the potential to rapidly escalate into global crises. In recent years, severe outbreaks of Ebola, Lassa, Zika, and other emerging viruses have illustrated how vulnerable the world is to threats from RNA viral pathogens. These public health emergencies have exposed the urgent need for improved infrastructure, scientific knowledge, and diagnostic tools in areas of the world most at risk, and underscore the need for proactive pathogen surveillance, detection, and discovery. West Africa has a disproportionate vulnerability to outbreaks, but we lack awareness of acute threats, their natural history, and effective strategies for prevention. Rooted research between local and global partners, combined with novel assays and strategies for pandemic preparedness is required to answer these questions. We will build the capacity to rapidly respond to future outbreaks by establishing the West African Research Network for Infectious Diseases. This network will expand on years of successful cross-disciplinary research and capacity building, bringing together leading researchers from the United States, Liberia, Nigeria, Senegal, and Sierra Leone. We will: (1) perform comprehensive surveys of acute RNA viral disease and determine critical threats circulating in hosts and reservoirs; (2) identify risk factors of virus transmission and evolution; (3) dissect pathogenesis and natural history of severe RNA viral diseases; and (4) determine diagnostic criteria for infection outcome to guide public health interventions. Our work will significantly expand research capacity in West Africa via technology development of novel solutions for surveillance, diagnostics, and pathogen discovery. By establishing our network with a focus on priority pathogen research, technology transfer, training, and capacity building, we will develop flexible strategies for detecting, mitigating, and preventing the emergence of future infectious disease outbreaks.

抽象的确保世界免受微生物威胁的保护是一个紧迫的挑战，因为爆发对人类健康的爆发，破坏了地区安全，并有可能快速升级为全球危机。近年来，埃博拉病毒，Lassa，Zika和其他新兴病毒的严重爆发表明，世界对RNA病毒病原体威胁的威胁有多么脆弱。这些公共卫生的紧急情况迫切需要改善世界地区最受危险的基础设施，科学知识和诊断工具，并强调了对积极的病原体监测，检测和发现的需求。西非对暴发的脆弱性不成比例，但我们缺乏对急性威胁，其自然历史和有效预防策略的认识。本地和全球合作伙伴之间的植根研究，再加上新颖的大流行准备的策略来回答这些问题。我们将通过建立西非传染病研究网络来迅速响应未来爆发的能力。该网络将扩大多年来成功的跨学科研究和能力建设，将来自美国，利比里亚，尼日利亚，塞内加尔和塞拉利昂的主要研究人员汇总在一起。我们将：（1）对急性RNA病毒疾病进行全面的调查，并确定宿主和水库中循环的关键威胁；（2）确定病毒传播和进化的危险因素；（3）剖析严重RNA病毒疾病的发病机理和自然史；（4）确定感染结果的诊断标准，以指导公共卫生干预措施。我们的工作将通过技术开发用于监测，诊断和病原体发现的新解决方案的技术开发，从而大大扩大西非的研究能力。通过建立我们的网络，重点关注病原体研究，技术转移，培训和能力建设，我们将制定灵活的策略，以检测，缓解和防止未来的传染病暴发的出现。

项目成果

期刊论文数量（19）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Streamlined inactivation, amplification, and Cas13-based detection of SARS-CoV-2.

DOI：
10.1038/s41467-020-19097-x
发表时间：
2020-11-20
期刊：
Nature communications
影响因子：
16.6
作者：
Arizti-Sanz J;Freije CA;Stanton AC;Petros BA;Boehm CK;Siddiqui S;Shaw BM;Adams G;Kosoko-Thoroddsen TF;Kemball ME;Uwanibe JN;Ajogbasile FV;Eromon PE;Gross R;Wronka L;Caviness K;Hensley LE;Bergman NH;MacInnis BL;Happi CT;Lemieux JE;Sabeti PC;Myhrvold C
通讯作者：
Myhrvold C

Space-Time Trends in Lassa Fever in Sierra Leone by ELISA Serostatus, 2012-2019.

DOI：
10.3390/microorganisms9030586
发表时间：
2021-03-12
期刊：
Microorganisms
影响因子：
4.5
作者：
Shaffer JG;Schieffelin JS;Momoh M;Goba A;Kanneh L;Alhasan F;Gbakie M;Engel EJ;Bond NG;Hartnett JN;Nelson DKS;Bush DJ;Boisen ML;Heinrich ML;Rowland MM;Branco LM;Samuels RJ;Garry RF;Grant DS;The Viral Hemorrhagic Fever Consortium
通讯作者：
The Viral Hemorrhagic Fever Consortium

Microbial metagenomic approach uncovers the first rabbit haemorrhagic disease virus genome in Sub-Saharan Africa.

DOI：
10.1038/s41598-021-91961-2
发表时间：
2021-07-01
期刊：
Scientific reports
影响因子：
4.6
作者：
Happi AN;Ogunsanya OA;Oguzie JU;Oluniyi PE;Olono AS;Heeney JL;Happi CT
通讯作者：
Happi CT

VGEA: an RNA viral assembly toolkit.

DOI：
10.7717/peerj.12129
发表时间：
2021
期刊：
PeerJ
影响因子：
2.7
作者：
Oluniyi PE;Ajogbasile F;Oguzie J;Uwanibe J;Kayode A;Happi A;Ugwu A;Olumade T;Ogunsanya O;Eromon PE;Folarin O;Frost SDW;Heeney J;Happi CT
通讯作者：
Happi CT

Simplified Cas13-based assays for the fast identification of SARS-CoV-2 and its variants.

DOI：
10.1038/s41551-022-00889-z
发表时间：
2022-08
期刊：
NATURE BIOMEDICAL ENGINEERING
影响因子：
28.1
作者：
Arizti-Sanz, Jon;Bradley, A'Doriann;Zhang, Yibin B.;Boehm, Chloe K.;Freije, Catherine A.;Grunberg, Michelle E.;Kosoko-Thoroddsen, Tinna-Solveig F.;Welch, Nicole L.;Pillai, Priya P.;Mantena, Sreekar;Kim, Gaeun;Uwanibe, Jessica N.;John, Oluwagboadurami G.;Eromon, Philomena E.;Kocher, Gregory;Gross, Robin;Lee, Justin S.;Hensley, Lisa E.;MacInnis, Bronwyn L.;Johnson, Jeremy;Springer, Michael;Happi, Christian T.;Sabeti, Pardis C.;Myhrvold, Cameron
通讯作者：
Myhrvold, Cameron